Ultrasound Assessment of Changes in the Diameter of the Common Carotid Artery After Increasing the Preload of the Heart

Withdrawn

• Conditions: Fluid Responsiveness; Critical Illness
• Interventions: Diagnostic Test: fluid responsiveness assessment

• Registration Number: NCT03412422
• Lead Sponsor: Uniwersytecki Szpital Kliniczny w Opolu

Brief Summary

Passive leg raise (PLR) and fluid challenge are useful tools in assessing the fluid responsiveness. However, they require continuous monitoring of cardiac output, which is usually an invasive technique and in some cases not always available. Vascular ultrasound can be an alternative to cardiac output monitoring in a fluid status evaluation. The common carotid artery (CCA) is an easily accessible vessel. It has recently been noted that the diameter of this artery changes after an intravenous fluid bolus. It is possible that the change in the diameter of the common carotid artery during passive leg raise and fluid challenge can be a predictor of fluid responsiveness.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-01-21
• Study First Submitted QC: 2018-01-25
• Study First Posted: 2018-01-26
• Study Start: 2019-06-01
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-20
• Last Update Posted: 2020-01-23
• Primary Completion: 2020-10-01
• Study Completion: 2020-10-01

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• mechanically ventilated patients with circulatory failure, who are monitored with PiCCO and need fluid responsiveness assessment

Exclusion Criteria

• contraindication for the volume administration (hydrostatic pulmonary edema or other evidence of fluid overload)
• contraindication for PLR test (e.g. after trauma)
• lack of possibility to examine the carotid arteries
• bilateral carotid surgery in the past
• bilateral anatomical defects of the carotid arteries
• unstable cardiac rhythm (e.g. atrial fibrillation)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Acute circulatory failure	fluid responsiveness assessment	Mechanically ventilated patients with acute circulatory failure, monitored with PiCCO method, who need fluid responsiveness assessment.

Primary Outcome Measures

Name	Time	Method
Changes in the diameter of the common carotid artery	1 minute after PLR test and 1 minute after fluid challenge	The diameter will be measured with ultrasound

Secondary Outcome Measures

Name	Time	Method
Evaluation the value of changes in the diameter of CCA as the predictor of fluid responsiveness.	1 minute after PLR test and 1 minute after fluid challenge	The changes in the diameter of CCA will be compared with the changes in cardiac output measured with PiCCO method.

Trial Locations

Locations (1)

Department of Anesthesiology and Intensive Care, Uniwersytecki Szpital Kliniczny w Opolu; 🇵🇱 Opole, Opolskie, Poland