Treatment-resistent depression in the elderly.
Completed
- Conditions
- Major depression.
- Registration Number
- NL-OMON28173
- Lead Sponsor
- ZON-MW
- Brief Summary
1. J Clin Psychiatry. 2007 Aug;68(8):1177-85.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
1. Male or female inpatient;
2. Aged 60 years or older;
Exclusion Criteria
1. Known hypersensitivity to lithium or phenelzine;
2. Previous unsuccessful adequate (minimal 15 mg during 4 weeks) treatment with phenelzine or with lithiumaugmentation (minimal serum level of 0.6 mmol/l during 4 weeks);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Efficacy: remission defined as a final score of 10 or less on the MADRS. <br /><br>Tolerability: Global Tolerability Score.<br />
- Secondary Outcome Measures
Name Time Method Response defined as a reduction of at least 50 % of MADRS, HAM-D and GDS, CGI 1-2. Remission on HAM-D, GDS. Number of (serious) side effects and drop out rate due to the study medication. MMSE-score, TMT, VLGT (cognitive tests).