NL-OMON56014招募中不适用
Focus on Energy Metabolism in Arrhythmogenic Cardiomyopathy - FUEL-cardiomyopathy
niversitair Medisch Centrum Utrecht0 个研究点目标入组 30 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •In order to be eligible to participate in this study, a subject must meet all
- •of the following criteria:
- •Affected ACM patients:
- •- Carrier of a (likely) pathogenic PKP2 variant (i.e. class 4 or 5 variant as
- •per American College of Medical Genetics guidelines).
- •- Fulfillment of definite ACM diagnosis as per 2010 Task Force Criteria.
- •- Written informed consent.
- •Preclinical ACM mutation carriers:
- •- Carrier of a (likely) pathogenic PKP2 variant (i.e. class 4 or 5 variant as
- •per American College of Medical Genetics guidelines).
- •- No fulfillment of definite ACM diagnosis as per 2010 Task Force Criteria.
- •- Written informed consent.
- •Healthy controls:
- •- No prior history of cardiac complaints.
- •- Normal echocardiogram.
- •- Normal ECG.
- •- Written informed consent.
排除标准
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •Affected and preclinical ACM mutation carriers:
- •- Not carrying a (likely) pathogenic PKP2 variant (i.e. class 4 or 5 variant as
- •per American College of Medical Genetics guidelines).
- •- Prior life-threatening arrhythmia during exercise (including sudden cardiac
- •arrest, ventricular fibrillation, sustained ventricular tachycardia,
- •appropriate implantable cardioverter-defibrillator intervention)
- •- Unwilling or unable to provide written informed consent
- •Healthy controls:
- •- Prior history of cardiac complaints
- •- Abnormal echocardiogram
- •- Abnormal ECG
- •- Unwilling or unable to provide written informed consent
研究者
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