In Vivo Cardiac Metabolism in Normal, Ischemic, and Cardiomyopathic Patients During Rest and Stress
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Phosphocreatine/adenosine triphosphate (PCr/ATP) and creatine kinase (CK) flux
研究概览
简要总结
The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.
详细描述
This study uses magnetic resonance (MR) spectroscopy to study heart metabolism and function in normal subjects and patients with left ventricular hypertrophy, dilated cardiomyopathy, and those with coronary artery disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age > 18 years
- •Healthy subjects: no history of heart disease
- •Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) <40%
- •Left ventricular hypertrophy: wall thickness >1.2cm
- •Coronary artery disease: >50% coronary lesion or positive stress test
排除标准
- •contraindication to MRI
结局指标
主要结局
Phosphocreatine/adenosine triphosphate (PCr/ATP) and creatine kinase (CK) flux
时间窗: At time of magnetic resonance spectroscopy (MRS)
Can non-invasive magnetic resonance imaging and spectroscopy techniques be developed, validated, and implemented on clinical MR scanners in order to address the questions of a.) the extent to which myocardial high-energy phosphate (HEP), creatine (Cr), or sodium concentrations change in response to and after transient ischemia or chronic ischemic injury, b.) the extent to which myocardial high-energy phosphates, creatine, or sodium concentrations as well as HEP flux are altered in cardiomyopathic patients with and without/ congestive heart failure, c.) can spatial differences in cardiac metabolites (HEP, Cr) or ions (Na) induced by ischemic injury be identified with novel, non-invasive imaging techniques?
次要结局
- [Cr] or total creatine (CR), or CR/water ratio(At time of MRS)
- Phosphocreatine (PCr)(At time of MRS)
- ATP(At time of MRS)
- Sodium (NA)(At time of MRS)
- 31P distribution or metabolite map(At time of MRS)
- ATP flux(At time of MRS)
- 23Na distribution or metabolite map(At time of MRS)
- CR distribution or metabolite map(At time of MRS)