The effect of physical activity on health outcomes in patients receiving allogeneic stem cell transplants

Not Applicable

• Conditions: Haematological Cancer; Allogenic Stem Cell Transplant Patients; Cancer - Leukaemia - Acute leukaemia; Cancer - Leukaemia - Chronic leukaemia; Cancer - Hodgkin's; Cancer - Lymphoma (non Hodgkin's lymphoma) - High grade lymphoma; Cancer - Lymphoma (non Hodgkin's lymphoma) - Low grade lymphoma; Cancer - Myeloma; Blood - Haematological diseases

• Registration Number: ACTRN12619000741189
• Lead Sponsor: The Baker Heart and Diabetes Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-05-17
• Last Update Posted: 16 September 2019

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1)Greater than or equal to 18 years of age, male or female
2)Scheduled to receive a myeloablative or reduced-intensity conditioning allogeneic SCT
3)Can exercise at the time of enrolment (e.g. walk up a flight of stairs)

Exclusion Criteria

1)Unable to perform exercise magnetic resonance imaging
2)Planned for an outpatient, non-myeloablative allogeneic SCT
3)Unable to speak/understand English

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
i.Peak oxygen uptake (VO2 peak, exercise test with ramp protocol),<br><br>[-At baseline (prior to allogenic stem cell transplant) <br>-12 weeks post transplant ];ii.Peak cardiac output (exercise cardiac magnetic resonance imaging)<br>[-At baseline (prior to allogeneic stem cell transplant)<br>-On completion of physical activity program approximately 16 weeks post stem cell transplant ]

Secondary Outcome Measures

Name	Time	Method
i. Quality of life -Functional Assessment of Cancer Therapy with Bone Marrow Transplant; FACT-BMT Questionnaire (Validated Questionnaire)[-Baseline<br>-Post inpatient (approximately 4 weeks post stem cell transplant) <br>-On completion of physical activity program approximately 16 weeks post stem cell transplant];ii. Fatigue Functional Assessment of Chronic Illness Therapy (FACIT-fatigue) Questionnaire (Validated Questionnaire)[-Baseline<br>-Post inpatient (approximately 4 weeks post stem cell transplant) <br>-On completion of physical activity program approximately 16 weeks post stem cell transplant];iii. Functional independence (defined as VO2 peak of >18mL/kg/min) (CPET testing (bike))[-Baseline<br>-On completion of physical activity program approximately 16 weeks post stem cell transplant]