The effect of moderate physical activity (briskwalking) on metabolic and inflammatory markers in people living with HIV

Completed

• Conditions: Inflammation; Physical inactivity; HIV infection; Metabolic problems; Inflammatory and Immune System - Other inflammatory or immune system disorders; Infection - Acquired immune deficiency syndrome (AIDS / HIV); Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12615001258549
• Lead Sponsor: San Raffaele Scientific Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-11-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Age: between 18 and 75 years of age;
HIV infection
cART: greater than 6 months;
Sedentary lifestyle: defined as physical activity for <2 days per week for <20 minutes per session;
Either evidence of lipodystrophy or of at least one of the Adult Treatment Panel III definition criteria of the metabolic syndrome

Exclusion Criteria

Any disease requiring hospitalization in the 6 weeks before enrolment; medical conditions contraindicating exercise as established by a sport medicine specialist; inability to walk at brisk pace; current substance or alcohol abuse.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Composite primary outcome: variation of metabolic markers including those defining the metabolic syndrome.<br><br>Triglycerides, HDL cholesterol and fasting glucose were collected at baseline and after 12 weeks of training; fasting blood samples were collected and processed locally according to standardized protocols.[Baseline and after 12 weeks of training];Waist Circumference was measured at baseline and after 12 weeks of training with a tape at the mid-point between the last costal arch and the iliac crest.[Baseline and after 12 weeks of training];Blood pressure was measured at baseline and after 12 weeks of training with a sphygmomanometer.[Baseline and after 12 weeks of training]