Cognitive Vulnerability Factors in Alcohol-dependence

Not Applicable

Terminated

• Conditions: Alcoholism
• Interventions: Behavioral: Diagnostic Interview for Genetic Studies; Behavioral: Family Informant Schedule and Criteria; Behavioral: Temperament and Character Inventory; Behavioral: Barratt Impulsiveness Scale; Behavioral: Wisconsin Card Sorting Test; Genetic: blood sample withdrawn

• Registration Number: NCT02842528
• Lead Sponsor: CHU de Reims

Brief Summary

The purpose of this study is to specify the cognitive and genetic pattern associated with alcohol dependence. Results will help identifying more precisely vulnerability factors associated with this disorder.

Detailed Description

Alcohol dependence involves both environmental and genetic vulnerability factors. Although it has a rather high degree of heritability (estimates range between 40% and 60%), vulnerability to alcohol dependence is broadly recognised as a complex polygenic phenotype. To clarify the risk factors involved in alcohol dependence, attempts have been made to identify endophenotypes in alcohol dependent patients and their relatives. Endophenotypes are defined as heritable traits associated with an increased risk for developing a disorder; they must be found in probands and their unaffected relatives at a higher rate than in the general population and must be associated with a specific genetic pattern. In the present study the investigators investigate the cognitive performance of alcohol dependent patients in comparison with a group of adult non-alcoholic offspring of alcohol-dependent patients and a group of participants without family history of alcohol dependence. The investigators also explore the relation between familial density of alcoholism and cognitive performance, particularly mental flexibility and inhibition. Genetic analysis will also be conducted to investigate the relationship between cognitive performance and genetic patterns (single nucleotide polymorphisms).

Study Timeline

• Study Start: 2007-09
• Primary Completion: 2009-03
• Study Completion: 2009-07
• Study First Submitted: 2016-06-27
• Status Verified: 2016-07
• Study First Submitted QC: 2016-07-20
• Last Update Submitted: 2016-07-20
• Study First Posted: 2016-07-25
• Last Update Posted: 2016-07-25

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 261

Inclusion Criteria

Alcohol-dependent patients :

• Males or females, aged 18-65 years, with a diagnosis of alcohol dependence, according to the DSM-IV criteria
• Patients withdrawn from alcohol at least 2 weeks
• Native French speaker, able to read French and complete study evaluations
• Caucasian
• Able to provide informed written and verbal consent

First-degree relatives of alcohol-dependent probands :

• Males or females, aged 18-65 years
• Caucasian
• Native French speaker, able to read French and complete study evaluations
• Able to provide informed written and verbal consent

Healthy Controls :

• Males or females, aged 18-65 years
• Caucasian
• Native French speaker, able to read French and complete study evaluations
• Able to provide informed written and verbal consent

Exclusion Criteria

Alcohol-dependent patients

• DSM-IV substance use disorder other than alcohol
• Severe chronic psychiatric disorders including Bipolar disorder and schizophrenia
• Mood episode diagnostic according to the DSM-IV criteria in the last six months
• A significant general medical illness, including neurological disorders
• A sensorial impairment uncorrected (visual and/or hearing)
• Individuals who are not covered by national health insurance

First-degree relatives of alcohol-dependent probands :

• Past or recent alcohol and/or drug abuse or dependence
• Severe chronic psychiatric disorders including Bipolar disorder and schizophrenia
• Mood episode diagnostic according to the DSM-IV criteria in the last six months
• A significant general medical illness, including neurological disorders
• Handling of psychotropics substances
• A sensorial impairment uncorrected (visual and/or hearing)
• Individuals who are not covered by national health insurance

Healthy Controls :

• A personal or first-degree-relative history of alcohol dependence
• Past or recent alcohol and/or drug abuse or dependence
• Total abstinence from alcohol
• Severe chronic psychiatric disorders including Bipolar disorder and schizophrenia
• Mood episode diagnostic according to the DSM-IV criteria in the last six months
• A significant general medical illness, including neurological disorders
• Handling of psychotropics substances
• A sensorial impairment uncorrected (visual and/or hearing)
• Individuals who are not covered by national health insurance

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Healthy Controls	Barratt Impulsiveness Scale	-
Healthy Controls	blood sample withdrawn	-
Alcohol-dependent patients	Wisconsin Card Sorting Test	-
First-degree relatives of alcohol-dependent probands	Barratt Impulsiveness Scale	-
First-degree relatives of alcohol-dependent probands	Wisconsin Card Sorting Test	-
Alcohol-dependent patients	blood sample withdrawn	-
Healthy Controls	Wisconsin Card Sorting Test	-
Alcohol-dependent patients	Family Informant Schedule and Criteria	-
Alcohol-dependent patients	Temperament and Character Inventory	-
Alcohol-dependent patients	Barratt Impulsiveness Scale	-
First-degree relatives of alcohol-dependent probands	Diagnostic Interview for Genetic Studies	-
First-degree relatives of alcohol-dependent probands	Family Informant Schedule and Criteria	-
First-degree relatives of alcohol-dependent probands	Temperament and Character Inventory	-
Healthy Controls	Temperament and Character Inventory	-
Alcohol-dependent patients	Diagnostic Interview for Genetic Studies	-
First-degree relatives of alcohol-dependent probands	blood sample withdrawn	-
Healthy Controls	Diagnostic Interview for Genetic Studies	-
Healthy Controls	Family Informant Schedule and Criteria	-

Primary Outcome Measures

Name	Time	Method
questionnaire	Day 0	comparison of questionnaires score for the 3 groups

Secondary Outcome Measures

Name	Time	Method
genetic polymorphism	Day 0

Trial Locations

Locations (1)

Chu de Reims; 🇫🇷 Reims, France