EUCTR2007-007276-41-AT进行中（未招募）不适用
Gene expression profiling in skeletal muscle of healthy subjects treated with ramipril - Ram_GEP_1
Medizinische Universität Wien, Universitätsklinik für Klinische Pharmakologie0 个研究点开始时间: 2008年3月17日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- Male
入选标准
- •Healthy defined as absence of relevant disease
- •Aged 18-45 years
- •BMI: 18-28 kg/m2
- •Signed informed consent
- •Blood pressure between 110/45 and <140/90 (twice at screening)
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •History of renal artery stenosis, angioneurotic edema, psoriasis, relevant renal diseases
- •RR at screening < 110/45 mmHg.
- •Diabetes, history of hypertension, RR > 140/90 at screening, cardiovascular disease
- •Known Diabetes mellitus of parents
- •HIV or Hepatitis B/C positive virology
- •Allergy or hypersensitivity against ACE-inhibitors / ramipril or to xylocain
- •Contraindications against the use of the drug according to the SmPC, history of angioedema
- •Any drug intake 2 weeks prior to first study day
- •History of excessive bleeding tendency / hemophilia
- •Presence of relevant illness within the last 3 weeks
- •Suspected non-compliance with study instructions and life-style requirements
- •Alcohol or drug abuse
- •Blood/Plasma donation within 4 weeks prior to study day
- •Previous exposure to antihypertensive drugs, ACE-inhibitors, in particular ramipril
- •Current smoking (any quantity), (at least 6 months of non-smoking required)
研究者
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