Characterization of skeletal muscle of patients with Becker-Kiener muscular dystrophy by 1H and X-nuclei MRI
- Conditions
- G71.0Muscular dystrophy
- Registration Number
- DRKS00032522
- Lead Sponsor
- niversitätsklinikum Erlangen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Ambulant, at least for short distances.
- Willingness and ability to participate, sufficient knowledge of German to understand the declaration of consent, or if not possible, test subject information and support in the mother tongue or, if necessary, in English
- Probability that the subjects/patients can complete the study (defined by the ability to lie still for approximately 1 hour)
- A signed declaration of consent is required for all subjects to participate in this study (the information and explanation sheet for subjects and patients is enclosed with the application).
- General contraindications for MRI examinations
- Electrical implants such as cardiac pacemakers or perfusion pumps
- Pronounced claustrophobia
- Study participants with ferromagnetic or electrically conductive implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, heart valves with metal parts, metal splinters, tattoos near the eye, symmetrical tattoos on the extremities or steel implants must be discussed with the study physician; they may not be examined (relative contraindications for MRI).
- Prohibited concomitant medication: Strongly sedating medications are to be ruled out, since intensive monitoring of body functions during ongoing imaging cannot be guaranteed and the examination is dependent on the active participation of the subject.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fat fraction (FF) and total sodium concentration (TSC) in lower leg muscles. <br>0, 12 months in patients<br>Once in healthy controls
- Secondary Outcome Measures
Name Time Method potassium concentration, phosphor metabolites, water T2 and T1 (transverse and longitudinal relaxation times) in the lower leg muscles. <br>