DRKS00033194
Recruiting
未知
Skeletal muscle phenotype and its association with glucometabolic status in patients with type 2 diabetes, overweight-to-obese and healthy individuals. - MuscleDiab
Deutsches Luft- und Raumfahrtzentrum, Institut für Luft- und Raumfahrtmedizin0 sites60 target enrollmentDecember 7, 2023
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- E11
- Sponsor
- Deutsches Luft- und Raumfahrtzentrum, Institut für Luft- und Raumfahrtmedizin
- Enrollment
- 60
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Individuals with T2D:
- •Female and male individuals with T2D diagnosis according to ADA criteria
- •No participation in structured exercise programs for \=6 months
- •BMI between 19 and 35 kg/m2
- •Age between 24 and 69 years
- •Signed informed consent
- •Overweight\-toobese individuals:
- •Female and male participants with
- •normal glucose tolerance
- •Sex\-, age\- and physical activity levelmatched to individuals with T2
Exclusion Criteria
- •Contra\-indications against biopsy (e.g. impaired hemostasis,
- •keloidosis, history of adverse reactions to local anesthesia or to surgical
- •procedures)
- •Contra\-indications against magnetic resonance imaging, including metal implants or other osteosynthesis material, not MRI compatible stents, clips
- •etc., pacemakers, infusion pumps, claustrophobia
- •neurological conditions
- •including strokes, brain hemorrhage, aneurysms, brain tumors,
- •neurodegenerative diseases, seizures, head trauma based on medical history
- •Cardiovascular conditions including acute coronary artery disease with coronary angina or myocardial infarction in the last 6 months,
- •heart failure (NYHA III\-IV), ventricular or atrial arrhythmias, pacemaker, recurrent syncope,
Outcomes
Primary Outcomes
Not specified
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