DRKS00033194招募中Unknown
Skeletal muscle phenotype and its association with glucometabolic status in patients with type 2 diabetes, overweight-to-obese and healthy individuals. - MuscleDiab
Deutsches Luft- und Raumfahrtzentrum, Institut für Luft- und Raumfahrtmedizin0 个研究点目标入组 60 人开始时间: 2023年12月7日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 招募中
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomized controlled study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 24 Years 至 69 Years（—）
- 性别
- All
入选标准
- •Individuals with T2D:
- •Female and male individuals with T2D diagnosis according to ADA criteria
- •No participation in structured exercise programs for =6 months
- •BMI between 19 and 35 kg/m2
- •Age between 24 and 69 years
- •Signed informed consent
- •Overweight-toobese individuals:
- •Female and male participants with
- •normal glucose tolerance
- •Sex-, age- and physical activity levelmatched to individuals with T2
- •No participation in structuredexercise programs for =6 months
- •BMI between 25 to 40 kg/m2
- •Signed informed consent
- •Normal-weight individuals:
- •Metabolically healthy female and male participants with normal glucose tolerance
- •Sex-, age- and physical activity levelmatched to individuals with T2D
- •No participation in structured exercise programs for =6 months
- •BMI between 19 to 24.9 kg/m2
- •Signed informed consent
排除标准
- •Contra-indications against biopsy (e.g. impaired hemostasis,
- •keloidosis, history of adverse reactions to local anesthesia or to surgical
- •procedures)
- •Contra-indications against magnetic resonance imaging, including metal implants or other osteosynthesis material, not MRI compatible stents, clips
- •etc., pacemakers, infusion pumps, claustrophobia
- •neurological conditions
- •including strokes, brain hemorrhage, aneurysms, brain tumors,
- •neurodegenerative diseases, seizures, head trauma based on medical history
- •Cardiovascular conditions including acute coronary artery disease with coronary angina or myocardial infarction in the last 6 months,
- •heart failure (NYHA III-IV), ventricular or atrial arrhythmias, pacemaker, recurrent syncope,
- •Autonomic disorders
- •Chronic pulmonary diseases (COPD, severe asthma, pulmonary fibrosis)
- •Sleep apnea, insomnia or narcolepsy based on medical history
- •Any other medical condition that the investigators consider contraindication to the study procedures that would make it unsafe or
- •confound the measurements, e.g. medication with insulin, sulfonylurea, glinide,medication influencing hemostasis (e.g. ASS, anticoagulants)
研究者
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