Acupuncture effect on cognitive improvement in patients with mild cognitive impairment
- Conditions
- Mental and behavioral disorders
- Registration Number
- KCT0002896
- Lead Sponsor
- Korea Institute of Oriental Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
1) Patients who meet the criteria for mild cognitive impairment (MCI)
2) Men and women aged 50 to 70
3) Suffering memory loss of more than 3 months
4) Education level of more than 6 years
5) a Korean-type Montreal Cognitive Assessment (MoCA-K) score < 23
6) a CDR (Clinical Dementia Rating) score of 0.5 and GDS (Global Deterioration Scale) grade 2-3
7) a Modified Hachinski Ischemic Score (HIS) score of 4 or less
8) Voluntarily signed the informed consent form
1) Patients who meet the criteria for dementia of DSM-5 (Diagnostic and Statistical Manual of Mental Disorder)
2) Presenting cerbral lesions or brain damage
3) History of cerebral hemorrhage or cerebral infarction
4) Neurological disorderssuch as Parkinson's disease, epilepsy, brain tumor, and etc.
5) Mental disorder such as major depressive disorder, schizophrenia, bipolar disorder, and etc.
6) Participations in other clinical trials within the last 4 weeks
7) Receiving acupuncture treatments within the last 4 weeks due to cognitive impairment
8) Taking medications related to dementia
9) Pregnant or lactating women
10) Obstructive phobia or metal implantation
11) Patient who have experienced hypersensitivity reactions after acupuncture treatment, or who are difficult to cooperate with acupuncture treatment
12) Others judged inappropriate as subjects by researchers
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Digit span test
- Secondary Outcome Measures
Name Time Method Digit span test;Digit Symbol Substitution Test (DSST);Korean Version of Montreal Cognitive Assessment (MoCA-K);Seoul Neuropsychological Screening Battery-II (SNSB-II);Korean Beck Depression Inventory-II (BDI-II);State-Trait Anxiety Inventory (STAI);working memory task performance score;Brain activity change by working memory task performance;Brain activity change by emotional image stimulation;Changes of cerebral blood flow;Changes in functional and structural networks of the brain;Adverse events