Multicenter and Prospective Clinical Registry Study of Anti-N-methyl-D-aspartate Receptor Encephalitis in Beijing Area

• Conditions: Anti-N-Methyl-D-Aspartate Receptor Encephalitis

• Registration Number: NCT02443350
• Lead Sponsor: Jia Wei Wang,MD

Brief Summary

Anti N-methyl-D-aspartate receptor encephalitis is an autoimmune encephalitis，found in recent years，producing the specific IgG antibody induced by the NMDA receptors.It is the most common curable disease among the non infectious-autoimmune encephalitis,usually has been misdiagnosed as other causes of encephalitis.Our previous study found that there are differences between the Chinese and the foreign in anti-NMDA receptor encephalitis such as the sex ratio, the rate of combined tumor and clinical manifestations.As a new found disease,the incidence rate has been underestimated.Therefore,to establish the Registry Research Database for Chinese group of anti-NMDA receptor encephalitis is imminent.This study will combine Beijing area's hospitals and foreign experts,depending on multicenter, prospective and registry method,to understand the incidence in Beijing area,to summarize and analyze the clinical data of patients.So,there will make a solid foundation for the subsequent Beijing area detection platform and other research.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06
• Status Verified: 2015-05
• Study First Submitted: 2015-05-10
• Study First Submitted QC: 2015-05-10
• Last Update Submitted: 2015-05-10
• Study First Posted: 2015-05-13
• Last Update Posted: 2015-05-13
• Primary Completion: 2017-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• Older than 6 months.
• Encephalopathy symptoms (change of mental state and consciousness level) persist for more than 24 hours;
• At least one or more clinical features of the followings: fever, epilepsy, focal neurological deficiency symptoms, changes in CSF(cerebrospinal fluid inflammatory), changes in EEG (electroencephalogram), radiographic abnormalities;
• Clinical suspected encephalitis, but conventional detected methods cannot make etiology clear

Exclusion Criteria

• Infants less than 6 months;
• The metabolic encephalopathy;
• Infectious encephalitis with clinically clear pathogen, referring the specific pathogenic microorganisms, including: bacteria, virus, fungus, parasite, spirochete and so on;
• Non-infectious encephalitis with clinically clear diagnosis, including: multiple sclerosis, optic neuromyelitis, acute disseminated encephalomyelitis and so on.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
death	24 months

Trial Locations

Locations (1)

Beijing Tongren Hospital,Capital Medical Universiy; 🇨🇳 Beijing, Beijing, China