Psycho-social Impact of Anti-NMDAR Encephalitis

Recruiting

• Conditions: NMDAR Antibody-associated Auto-immune Encephalitis

• Registration Number: NCT05954468
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

NMDA receptor encephalitis is a rare neurological autoimmune disease with severe neuropsychiatric symptoms, but a typically good functional neurological outcome. The majority of patients experience long-term cognitive, psychological and social impairments that have significant consequences for their well-being and quality of life. However, as the disease was only recently discovered (Dalmau and al. Annals of neurology, 2007), this psycho-social impact has not been studied systematically and the resulting consequences for patients are not adequately appreciated.

The proposed study aims at characterizing the cognitive and psycho-social long-term consequences of this rare disease. Our main hypothesis is that NMDAR encephalitis has a persistent and clinically relevant impact on the patients' long-term cognitive, psychological and social well-being. Furthermore, we hypothesize that longterm subjective outcomes depend on both internal and external factors, such as acute disease course, access to post-acute care, caregiver support, personal coping strategies, or access to health education resources and peer group support.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-07-13
• Study First Submitted QC: 2023-07-13
• Study First Posted: 2023-07-20
• Status Verified: 2023-08
• Study Start: 2023-10-09
• Last Update Submitted: 2023-10-24
• Last Update Posted: 2023-10-25
• Primary Completion: 2024-10-09
• Study Completion: 2024-10-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Patients with anti-NMDAR encephalitis
• Year ≥ 18 ans
• Patients affiliated to the social security scheme

Exclusion Criteria

• Patients with no anti-NMDAR encephalitis
• Minor patient
• Patient under guardianship or curatorship
• Patient with preexisting neurological symptoms

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive and psycho-social analyses of patients with NMDAR encephalitis.	At study completion in an average of 12 months	The analyze will focus on the post-acute phase of the disease.

Trial Locations

Locations (1)

Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites auto-immunes, Hôpital neurologique Pierre Wertheimer; 🇫🇷 Bron, France