Cut-off Values of Muscle Thickness Ratio for Sarcopenia

Not Applicable

Completed

• Conditions: Sarcopenia
• Interventions: Other: Ultrasonographic evaluation

• Registration Number: NCT03993405
• Lead Sponsor: Hacettepe University

Brief Summary

The loss of muscle mass is one of the major diagnostic criteria for sarcopenia. Many methods are also used for the definition of sarcopenia. However there is no information about cut-off values in this respect in the literature. Therefore, the aim of this study is to determine the cut-off values of this ratio for confirming the diagnosis of sarcopenia.

Detailed Description

Decreases in total skeletal muscle mass are accepted to be necessary for confirming the diagnosis of sarcopenia. Many methods are also used for the definition of sarcopenia.

However, ultrasound measurements has a high sensitivity and specify for confirming the diagnosis of sarcopenia. However there is no information about cut-off values in this respect in the literature. Therefore, the aim of this study is to determine the cut-off values of this ratio for confirming the diagnosis of sarcopenia.

Study Timeline

• Study Start: 2019-01-01
• Status Verified: 2019-06
• Study First Submitted: 2019-06-18
• Study First Submitted QC: 2019-06-19
• Study First Posted: 2019-06-20
• Primary Completion: 2019-07-30
• Study Completion: 2019-08-09
• Last Update Submitted: 2019-08-10
• Last Update Posted: 2019-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 292

Inclusion Criteria

• To be a volunteer to participate
• To be an aged 18-90 years old.

Exclusion Criteria

• Walking with assist device
• Having a visual deficits
• Having an undergone orthopedic surgery
• Having a cardiac pacemaker
• Having a hypothyroidism, diabetes mellitus, renal/hepatic failure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control Group:Middle-aged	Ultrasonographic evaluation	Sixty middle-aged subjects will be evaluated in this study.
Experimental group:older	Ultrasonographic evaluation	Sixty older subjects will be evaluated in this study.
Control group:young	Ultrasonographic evaluation	Sixty older subjects will be evaluated in this study.

Primary Outcome Measures

Name	Time	Method
Muscle thickness	30 minutes	Muscle thickness in millimeters by Ultrasound.
Skeletal muscle mass	2 minutes	Skeletal muscle mass will be evaluated by bioelectrical impedance analysis.The unit of measure is kg.

Secondary Outcome Measures

Name	Time	Method
Muscle strength	15 minutes	Muscle strength will be evaluated using an isokinetic dynamometer (Biodex Medical Systems, New York, USA). Knee and ankle muscle strength( flexion, extension, dorsiflexion and plantarflexion) will be evaluated. The unit of measure is Nm/kg.
Peripheral strength	1 minutes	The peripheral (handgrip) strength will be measured with a dynamometer (JAMAR).Three measurements will be taken, whose average of the three measurements will be collected. The unit of measure is kg.
Physical function	5 minutes	Physical function will be evaluated by short physical performance scale. The score of this scale range from 0 (worst performance) to 12 (best performance).
Anthropometric assessments	5 minutes	Participants waist, hip and calf circumferences will be measured by tape measure. The unit of measure is centimeters.
Balance	1 minute	Timed up and go test evaluates dynamic balance of participants. The timed up and go test measures the time that a patient needs to stand up from a chair, walk a 3-m distance, come back and sit back on the chair.Timed up and go test measure is second. The lower values indicates the better balance.
Body mass index	1 minute	Participants' weight and height will be evaluated by electronic weighing and tape measure, respectively. body mass index will be expressed in in kg/ m²

Trial Locations

Locations (1)

Ozden Ozkal; 🇹🇷 Ankara, Turkey