Methylene Blue and Ozone in Early Sepsis
Phase 4
- Conditions
- Sepsis
- Interventions
- Registration Number
- NCT02910765
- Lead Sponsor
- Assiut University
- Brief Summary
effects of methylene blue and ozone O3 therapy effects in early sepsis management , and their implications upon outcome
- Detailed Description
effects of methylene blue on inducible nitric oxide messenger RNA transcription and protein expression are well evident in vasoplegia ,and septic shock . In the same time , ozone O3 therapy is also valuable in immune-modulation in multiple pathologies . our study collaborate both methylene blue and Ozone in early sepsis management , and we will evaluate the global medical progress , ICU stay , Morbidity and mortality
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- early sepsis Adults patients
Exclusion Criteria
- cardiac problems Glucose-6-Phosphate-Dehydrogenase Insufficiency Ozone Allergy Recent Myocardial Infarction Active Hyperthyroidism Thrombocytopenia Pregnancy Contraindications
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description M methylene blue and ozone methylene blue intravenous methylene blue and blood mixed with ozone ozone injection in early sepsis patients M methylene blue and ozone ozone intravenous methylene blue and blood mixed with ozone ozone injection in early sepsis patients P Placebo saline infusion saline and oxygen mixed blood injection in early sepsis patients P Placebo oxygen saline and oxygen mixed blood injection in early sepsis patients
- Primary Outcome Measures
Name Time Method APACHE score 7 days
- Secondary Outcome Measures
Name Time Method ICU stay 30 days