Methylene Blue and Ozone in Early Sepsis , a Randomized Double Blind Trial
试验速览
- 阶段
- 4 期
- 入组人数
- 40
- 主要终点
- APACHE score
研究概览
简要总结
effects of methylene blue and ozone O3 therapy effects in early sepsis management , and their implications upon outcome
详细描述
effects of methylene blue on inducible nitric oxide messenger RNA transcription and protein expression are well evident in vasoplegia ,and septic shock . In the same time , ozone O3 therapy is also valuable in immune-modulation in multiple pathologies . our study collaborate both methylene blue and Ozone in early sepsis management , and we will evaluate the global medical progress , ICU stay , Morbidity and mortality
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •early sepsis Adults patients
排除标准
- •cardiac problems Glucose-6-Phosphate-Dehydrogenase Insufficiency Ozone Allergy Recent Myocardial Infarction Active Hyperthyroidism Thrombocytopenia Pregnancy Contraindications
研究组 & 干预措施
M methylene blue and ozone
intravenous methylene blue and blood mixed with ozone ozone injection in early sepsis patients
干预措施: methylene blue (Drug)
M methylene blue and ozone
intravenous methylene blue and blood mixed with ozone ozone injection in early sepsis patients
干预措施: ozone (Drug)
P Placebo
saline and oxygen mixed blood injection in early sepsis patients
干预措施: saline infusion (Other)
P Placebo
saline and oxygen mixed blood injection in early sepsis patients
干预措施: oxygen (Other)
结局指标
主要结局
APACHE score
时间窗: 7 days
次要结局
- ICU stay(30 days)
研究者
Emad Zarief , MD
Lecturer of Anesthesia and critical care Medicine
Assiut University