Human thermoregulatory behavior and thermo-physiology before and after mild heat acclimation in healthy lean and obese subjects

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 48

Inclusion Criteria

Caucasian healthy lean volunteers
* Generally healthy
* male or female
* Age: 18 to 35 years
* BMI: 20-25 kg/m2
* Women using Microgynon 30 or levonorgestrel/ehinylestradiol;Inclusion criteria obese vrijwilligers
* Generally healthy
* male or female
* Age 18 to 35 years
* BMI 28-35 kg/m2
* Women using Microgynon 30 or levonorgestrel/ethinylestradiol

Exclusion Criteria

* Participants that do not want to be informed about accidental medical findings, which might occur during the study.
o If participants do not want us to inform their general practitioners about unexpected medical findings, they cannot participate in the study.;* Participate in physical activity more than 2x/week
o We will exclude individuals that participate in endurance sports (like swimming, running, cycling) more than two hours per week. Endurance-trained athletes seem to have differing thermo-physiology, which has, amongst others, been recently confirmed by another study of our laboratory (Vosselman et al, submitted).
* Participation in another biomedical study within 1 month before the first screening visit
* Diabetes mellitus type I and II
* Pregnancy
* Unstable weight (weight gain or loss > 5 kg in the last three months)
* Hypertension (systolic/diastolic blood pressure >140/90)
* Hypotension (systolic/diastolic blood pressure <90/60)
* General feeling of illness at day of experiment
* (History of) cardiovascular diseases
* Contraindications for the telemetric pill:
o In the presence of any known or suspected obstructive disease of the gastrointestinal tract, including but not limited to diverticulitis and inflammatory bowel disease
o A history of disorders or impairment of the gag reflex
o Previous gastrointestinal surgery
o Hypo motility disorders of the gastrointestinal tract including but not limited to Illeus

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. To study thermoregulatory behavior and thermo-physiology of healthy lean and<br /><br>obese subjects before and after mild heat acclimation.<br /><br>2. To define categories of temperature preference based on thermoregulatory<br /><br>behavior and thermo-physiology of healthy lean and obese subjects.<br /><br>3. To study the influence of mild heat acclimation on alertness and<br /><br>cardiovascular health of healthy lean and obese subjects. </p><br>

Secondary Outcome Measures