Ocular Pulse Amplitude And Choroidal Laser Doppler Flowmetry

Terminated

• Conditions: Healthy

• Registration Number: NCT00409110
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

This study intends to investigate the relationship between choroidal blood flow and ocular pulse amplitude (OPA).

Detailed Description

One eye is randomly selected in 18 healthy subjects. OPA is assessed with Dynamic Contour Tonometry. Submacular choroidal blood flow is measured with Laser Doppler Flowmetry. During both examinations the systemic blood pressure is continuously recorded with Finometer. An average systolic and diastolic LDF parameter flow during 30 seconds are determined and the pulsatility index is calculated according to the formula (LDFsys-LDFdia)/LDFdia. An association of OPA with the LDF pulsatility index, systemic blood pressure values and mean intraocular pressure will be analysed.

Study Timeline

• Study Start: 2006-01
• Study First Submitted: 2006-12-07
• Study First Submitted QC: 2006-12-07
• Study First Posted: 2006-12-08
• Status Verified: 2011-08
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Last Update Submitted: 2011-08-08
• Last Update Posted: 2011-08-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Healthy subjects should present no history of ocular diseases, of current topical medication, or of drug or alcohol abuse. Furthermore, a best corrected visual acuity above 20/25 in both eyes, lack of pathological findings upon a slit-lamp examination and dilated direct fundoscopy, and an IOP < 21 mmHg in both eyes will be required.

Exclusion Criteria

• History of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis.
• History of ocular trauma or intraocular surgery. History of infection or inflammation within the past 3 months.
• History and clinical evidence for other retinal disease such as age-related degeneration, or diabetic retinopathy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
An association of OPA with the LDF pulsatility index	30 seconds

Secondary Outcome Measures

Name	Time	Method
An association of OPA with the systemic blood pressure values	30 seconds
An association of OPA with mean intraocular pressure	30 seconds

Trial Locations

Locations (1)

University Eye Clinic Basel; 🇨🇭 Basel, Basel-Stadt, Switzerland