Registry Describing Clinical Information, Conventional, and Advanced Magnetic Resonance Imaging Information of Patients With Brain Glioma
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 9,000
- 试验地点
- 1
- 主要终点
- Documentation of radiologic information of conventional MR imaging and advanced MR imaging
研究概览
简要总结
This registry aims to collect clinical and radiologic information including detailed clinical, conventional MR and advanced MR imaging data of patients with brain gliomas. Advanced MR imaging may include diffusion-weighted imaging, perfusion-weighted imaging (dynamic susceptibility contrast, arterial spin labeling, dynamic contrast enhancement), and chemical exchange saturation transfer (CEST) imaging. This registry will describe course of disease and long-term outcomes of brain gliomas.
详细描述
Though the cure for brain glioma- from low grade to glioblastoma- is yet to be found, seeking for curable treatment option is actively developing. Multimodal advanced MR imaging (contrast-enhanced T1 weighted imaging, diffusion-weighted imaging, chemical exchange saturation transfer imaging, and perfusion imaging) on 3 Tesla have shown potential in patients with glioma to monitor treatment response with quantitative assessment. To find suitable imaging biomarker for treatment response, assessing clinical and radiologic outcome for long-term is essential. The creation of a registry for brain glioma in long-term follow up provides an overview of the clinical, relevant treatment standards, advanced MR imaging information, and survival data of patients and thus create opportunities for imaging biomarker research.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have radiologically and histologically confirmed diagnosis of Brain Glioma
- •Life expectancy of greater than 3 months
- •Must receive a first- or second-line therapy
- •Signed informed consent
排除标准
- •No brain gliomas
- •Patients who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulates, electronic infusion pumps, etc), because such devices may be displaced or malfunction
- •Patients who are pregnant or breast feeding; urine pregnancy test will be performed on women of child bearing potential
结局指标
主要结局
Documentation of radiologic information of conventional MR imaging and advanced MR imaging
时间窗: 5 years per patient
Documentation of clinical information (demographics and Karnofsky performance score)
时间窗: 5 years per patient
Documentation of treatment
时间窗: 5 years per patient
次要结局
- Progression Free Survival (PFS)(On-study date to lesser of date of progression or date of death from any cause (assessed at 6 months))
- One- year survival(One year)
- Identification of Imaging biomarkers of clinical significance (prognostic)(5 years)
- Overall Survival(5 years)
研究者
Ho Sung Kim
Associate Professor
Asan Medical Center