68Ga-FAPI PET/CT to detect ongoing fibroblast activity in post-acute COVID-19 with respiratory impairment after hospital discharge: *The FAPI COVID-CLIMATE Study*
- Conditions
- pulmonary fibrosis - connective tissue formation in the lungs10024970
- Registration Number
- NL-OMON53415
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
- Male patients 18 years or older and female patients 20 years or older,
discharged from hospital after PCR-confirmed COVID-19.
- Previous ICU and/or ward admission with high flow nasal oxygen (HFNO) or
mechanical ventilation.
- Persistent respiratory complaints at least 3 months after discharge
(shortness of breath).
- Registered diffusing capacity for carbon monoxide (DLCO) and vital capacity
(VC).
- Inability or unwilling to give informed consent.
- History of claustrophobia or feeling of inability to tolerate supine position
for the PET/CT scans.
- Severe or significant comorbidityI, defined as COPD GOLD stage II or higher,
known interstitial lung disease and/or an ASA score of IV or higher.
- Women who are pregnant or breastfeeding.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Fibroblast activity measured by FAPI-PET/CT </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Interstitial lung abnormalities (ILA) on high resolution computed tomography<br /><br>(HRCT)<br /><br>- 6-minute walking test (6MWT)<br /><br>- Inflammatory and fibrosis blood markers<br /><br>- Self reported daily impairments (EQ5D questionnaire)</p><br>