Endurance performance, cardiac autonomic risk factors and brain networks at epilepsies

Completed

• Conditions: G40; Epilepsy

• Registration Number: DRKS00014822
• Lead Sponsor: niversität Paderborn Sportmedizinisches Institut

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-06-01
• Study Completion: 2021-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

Epilepsy group: diagnosed epilepsy (all epilepsy syndroms)
Control group: healthy adult people

Exclusion Criteria

EPILEPSY GROUP
• physical disabilities that preclude participation in a physical stress test
• physical activity provoke epileptic seizures
• cardiovascular diseases such as ischemic or structural heart disease
o Myocardial diseases
o Heart valve disorders (moderate to severe stenosis or insufficiency)
o Congenital diseases
o Arrhythmias
o Hypertonic obstructive cardiomyopathy
• myo-, endo-, pericarditis
• cardiac surgery such as coronary angioplasty or revascularization surgery
• moderate to severe hypertension
• neurovascular or peripheral arterial disease
• angina pectoris
• severe pulmonary hypertension
• thromboembolic processes
• Blood coagulation disorders
• Taking blood thinners, such as Marcumar
• cardiac infarction
• resting blood pressure of >220/120 mmHg
• taking beta-blockers
• brain lesions
• acute feverish infections

CONTROL GROUP
• single epileptic seizure
• physical disabilities that preclude participation in a physical stress test
• cardiovascular diseases such as ischemic or structural heart disease
o Myocardial diseases
o Heart valve disorders (moderate to severe stenosis or insufficiency)
o Congenital diseases
o Arrhythmias
o Hypertonic obstructive cardiomyopathy
• myo-, endo-, pericarditis
• cardiac surgery such as coronary angioplasty or revascularization surgery
• moderate to severe hypertension
• neurovascular or peripheral arterial disease
• angina pectoris
• severe pulmonary hypertension
• thromboembolic processes
• Blood coagulation disorders
• Taking blood thinners, such as Marcumar
• cardiac infarction
• resting blood pressure of >220/120 mmHg
• taking beta-blockers
• brain lesions
• acute feverish infections

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Spirometry parameters<br>• Maximum oxygen consumption (VO2max) (Spirometry, Metalyzer 3B, CORTEX)<br>a) during exercise test<br>Parameters of the autonomic nervous system (ANS)<br>• mean tonic electro dermal activity (EDA) (electro dermal wrist sensors, E4, Empatica)<br>a) during resting state before and after exercise test<br>b) during exercise test<br>• root mean square of successive differences” (RMSSD) (Elektrocardiogram, custo cardio 100 BT, custo med)<br>a) during resting state before and after exercise test<br>b) during exercise test<br>Parameters of the electrical brain activity<br>• functional connectivity (Electroenzephalogram, 128 actiCap Aktivelektroden, Brain Products)<br>a) during resting state before and after exercise test<br>