Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 25
- Locations
- 2
- Primary Endpoint
- Spectometry to measure hemoglobin rate
Study Overview
Brief Summary
The inclusion of short periods of apnea (several seconds) during exercise (i.e. dynamic apnea) induces a significant decrease in blood oxygenation and muscle tissue. To date, the immediate effects ("acute apnea") of this decrease in the quantity of oxygen available at the muscle and brain level are poorly understood. Moreover, a physical training during which these short periods of apnea ("chronic apnea") would be included could lead to physiological adaptations and to improvement in physical performance similar to those obtained during altitude training.
The purpose of this study is to evaluate the effects of acute dynamic apnea on metabolism.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •The cutaneous thickness at the vastus lateralis level lower than 1.5 cm to obtain the reliable muscle oxygenation measurement
- •Subjects will have to sign the inform consent before the beginning of the study
Exclusion Criteria
- •Contraindications to regular physical exercise practice
- •To practice an endurance sport more than 1h/week
- •Regular practice of apnea
- •Chronic use of cannabis and/or alcohol
- •Cardiac or metabolic pathology
- •Asthma and/or bronchodilatator treatment
- •ECG abnormality at rest
- •Regular consumption of tobacco
Arms & Interventions
Apnea Group (GApn)
Program of training with exercises including apneas
Intervention: Program of training with exercises including apnea (Other)
Control Group (GC)
Program of training with exercises without apnea
Intervention: Program of training with exercises without apnea (Other)
Outcomes
Primary Outcomes
Spectometry to measure hemoglobin rate
Time Frame: 3 weeks
Measurement of oxygenation
Wingate test to measure maximum consumption of dioxygen
Time Frame: 3 weeks
Measurement of aerobic performance
Measurement of hormonal markers
Time Frame: 12 weeks
Measurement of Dehydroepiandrostenedione (DHEA)
Jaeger debimeter system to measure of peak oxygen
Time Frame: 12 weeks
Measurement of oxygen consumption,
Spectometry to measure hemoglobin
Time Frame: 12 weeks
Measurement of oxygenation
Measurement of arterial saturation in dioxygen
Time Frame: 12 weeks
Measurement by ear blood micro-sample
Secondary Outcomes
- Cardiac frequency(12 weeks)
- Borg scale to measure penibility of the effort(week 12)