Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects

Not Applicable

Completed

• Conditions: Apnea

• Registration Number: NCT03095677
• Lead Sponsor: Centre Hospitalier Régional d'Orléans

Brief Summary

The inclusion of short periods of apnea (several seconds) during exercise (i.e. dynamic apnea) induces a significant decrease in blood oxygenation and muscle tissue. To date, the immediate effects ("acute apnea") of this decrease in the quantity of oxygen available at the muscle and brain level are poorly understood. Moreover, a physical training during which these short periods of apnea ("chronic apnea") would be included could lead to physiological adaptations and to improvement in physical performance similar to those obtained during altitude training.

The purpose of this study is to evaluate the effects of acute dynamic apnea on metabolism.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-04-08
• Study First Submitted: 2016-09-27
• Study First Submitted QC: 2017-03-24
• Study First Posted: 2017-03-30
• Primary Completion: 2017-11-20
• Study Completion: 2017-11-20
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-02
• Last Update Posted: 2018-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 25

Inclusion Criteria

• The cutaneous thickness at the vastus lateralis level lower than 1.5 cm to obtain the reliable muscle oxygenation measurement
• Subjects will have to sign the inform consent before the beginning of the study

Exclusion Criteria

• Contraindications to regular physical exercise practice
• To practice an endurance sport more than 1h/week
• Regular practice of apnea
• Chronic use of cannabis and/or alcohol
• Cardiac or metabolic pathology
• Asthma and/or bronchodilatator treatment
• ECG abnormality at rest
• Regular consumption of tobacco

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Spectometry to measure hemoglobin rate	3 weeks	Measurement of oxygenation
Wingate test to measure maximum consumption of dioxygen	3 weeks	Measurement of aerobic performance
Measurement of hormonal markers	12 weeks	Measurement of Dehydroepiandrostenedione (DHEA)
Jaeger debimeter system to measure of peak oxygen	12 weeks	Measurement of oxygen consumption,
Spectometry to measure hemoglobin	12 weeks	Measurement of oxygenation
Measurement of arterial saturation in dioxygen	12 weeks	Measurement by ear blood micro-sample

Secondary Outcome Measures

Name	Time	Method
Cardiac frequency	12 weeks	measurement with a 12 lead - Electrocardiogramm
Borg scale to measure penibility of the effort	week 12

Trial Locations

Locations (1)

CHR d'Orléans; 🇫🇷 Orléans, France