Cohort of hepatitis B research in Amsterdam.

Recruiting

• Conditions: cirrhosis, hepatitis B virus, hepatocellular carcinoma, viral load

• Registration Number: NL-OMON21330
• Lead Sponsor: niversity Medical Center UtrechtPublic Health Service (GGD) Amsterdam

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 172

Inclusion Criteria

1. HBsAg-positivity;

2. Serum sample available from the screening programme at the Public Health Service;

Exclusion Criteria

1. Subjects coinfected with human immunodeficiency virus (HIV), hepatitis D virus (HDV) or
hepatitis C virus (HCV);

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main study parameters are any of following complications:<br /><br>1. Liver cirrhosis;<br /><br>2. Death related to HBV morbidity.

Secondary Outcome Measures

Name	Time	Method
Secondary study parameters are:<br /><br>1. HCC;<br /><br>2. Liver transplantation;<br /><br>3. End-stage liver disease (Child-Pugh B or C);<br /><br>4. Viral load of hepatitis B (comparison of historic and follow-up serum samples);<br /><br>5. Parameters of activation, exhaustion and apoptosis in various subsets of immunological cells.