Cohort of hepatitis B research of Amsterdam

• Conditions: Liver cirrhosis; Hepatitis B; 10019654; 10047438

• Registration Number: NL-OMON36693
• Lead Sponsor: Gemeentelijke GezondheidsDienst (GGD) Amsterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 172

Inclusion Criteria

All subjects must meet the following criteria:
-HBsAg-positivity
-Historic serum sample available from the screening programme at the Public Health Service
-Still living in the greater Amsterdam area and address traceable by general practitioners or death confirmed by general practitioner.
-Non-Asian (both parents not born in Asia)
-Between 18-65 years old
-Informed consent

Exclusion Criteria

Exclusioncriteria are:
- Subjects coinfected with human immunodeficiency virus (HIV) or hepatitis C virus (HCV)
- Subjects who are unable to come to the outpatient clinic
- Subjects incapable of informed consent due to legally incompetence

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters are any of following complications:<br /><br>-liver cirrhosis<br /><br>-death</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are:<br /><br>-hepatocellular carcinoma<br /><br>-liver transplantation<br /><br>-liver failure (Child-Pugh B or C)<br /><br>-viral load of hepatitis B (comparison of historic and follow-up serum samples)<br /><br>-parameters of activation, exhaustion and apoptosis in various subsets of<br /><br>immunological cells</p><br>