Fetal Bladder size

Conditions: Megablaas, megacystis, LUTO (Lower Urinary Tract Obstructions), urethrale kleppen, urethra atresie, Urinewegobstructie

Registration Number: NL-OMON23144

Lead Sponsor: niversity Medical Center Groningen (UMCG)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 300

Inclusion Criteria

Physiological singleton pregnancy in healthy women aged 18 or older, carrying a fetus without structural anomalies and capable of reading the Dutch language will be recruited at the dating scan (10-14 weeks).

Moreover twenty cases referred to our Fetal Unit for fetal mild pyelectasy, defined as an anteroposterior diameter of renal pelvis between 5-10 mm, will be included in the study.

Exclusion Criteria

Incapacitated adults, maternal disease that are likely to affect the fetal growth (hypertension requiring therapy, diabetes mellitus), multiple pregnancies, the presence of fetal malformation, abnormal karyotype or any other disease at birth.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Construction of reference curves for fetal bladder diameters and volume in the second and third trimester of pregnancy. .

Secondary Outcome Measures

Name	Time	Method
The variation in the dimensions of renal pelvis in relation to the degree of bladder filling in healthy fetuses compared to 20 cases with mild pielectasy (defined as an antero-posterior renal pelvis between 5 and 10 mm) will be investigated. Moreover, we will prospectively validate both the cut-off of bladder enlargement derived from this study in 20 cases of megacystis diagnosed in subsequent years