To compare the effect of two drugs named lignocaine and ropivacaine on reducing the rise in blood pressure and heart rate that happens during begining of anaesthesia and at termination of anaesthesia.

Completed

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2017/10/010254
• Lead Sponsor: Dr Ramyavel

Brief Summary

Both intubation and extubation is associated with hemodynamic changes . To reduce this response we aimed at using local anaesthetics i.e. ropivacaine 0.25% and lignocaine 2% topically .Both the drugs will be given via nebulisation prior to induction. After IEC approval 60 patients of age group 18 to 60 years belonging to ASA 1 and ASA 2 undergoing surgery under general anaesthesia will be enrolled in the double blind study.About 20 min before induction, patients will be given either of the drug via nebulisation. Anaesthesia induction and intubation  and extubation will be according to standard protocol. Hemodynamic parameters ie HR, MAP and spo2 will be recorded at various time points. Severity  of cough and time to extubation will also be recorded.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-30
• Study Completion: 2018-10-04
• Last Update Posted: 2019-11-18

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA 1 and ASA 2 Patients posted for surgery under general anaesthesia.

Exclusion Criteria

• 1. duration of surgery >3 hours.
• 2. surgery involving the airway.
• 3. patients with history of respiratory disease or LRI.

• 4. 3 attempts at laryngoscopy or intubation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hemodynamic parameters ( Heart rate, Mearn arterial Pressure and saturation) at the time of intubation and extubation.	MAP, HR, and Spo2 at; | A)Baseline (T1) | B)Upon tracheal intubation (T2) | C)Upon anaesthetic withdrawal (T3) | D)Upon eye opening on verbal commands (T4) | E)Upon tracheal extubation (T5) | F)2 min after extubation (T6)

Secondary Outcome Measures

Name	Time	Method
1) severity of cough at extubation	2) time to extubation

Trial Locations

Locations (1)

Pondicherry institute of Medical sciences; 🇮🇳 Pondicherry, PONDICHERRY, India

Pondicherry institute of Medical sciences

🇮🇳Pondicherry, PONDICHERRY, India

Dr Ramyavel

Principal investigator

9487630425

ramyavel1988@gmail.com