Analysing the Effects of Coupling Nebulization to Noninvasive Ventilation Through Pulmonary Scintigraphy on the Radioaerosol Deposition During Asthma Exacerbation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Cardiopulmonary characteristics
研究概览
简要总结
Despite the physiologic and clinical effects provided by coupling nebulization with noninvasive ventilation in asthma exacerbation, there are few and controversial studies reported in the literature.
详细描述
Reduced work of breathing, increased oxygenation and increased in expiratory peak flow (EPF) and forced expiratory volume in the first second (FEV1) are benefits of noninvasive ventilation (NV) in the treatment of asthma. Despite these clinical improvements attributed to NV during asthma exacerbations and the well-established effects of nebulization, there are few studies in the literature coupling both therapeutic resources.
In addition to this, no studies on scintigraphic analysis of radioaerosol deposition coupled with NV in asthmatics have published. A previous study was published by our group, but involved healthy subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of moderate to severe asthma (FEV1 < 60 % of predicted values)
- •Breathing rate > 25 bpm
- •History of asthma for at least 1 year
- •Duration of current asthma attack of < 7 days
- •Reversibility of FEV1 of at least ≤ 10% after the administration of bronchodilator drugs
排除标准
- •Current smoker
- •Presence of cardiopulmonary disease (COPD, pneumonia, heart failure, myocardial infarction, pneumothorax)
- •Hyperthermia
- •Indication of intubation and invasive mechanical ventilation;
- •Hemodynamic instability (heart rate > 150 bpm and systolic blood pressure < 90 mmHg)
- •Cardiac arrhythmia
- •Changes in consciousness
- •Pregnancy
- •Contraindications to use NV
结局指标
主要结局
Cardiopulmonary characteristics
时间窗: 6 months
次要结局
- Radioaerosol pulmonary index, radioaerosol penetration index and pulmonary clearance.(6 months)