PACTR202112749708968
Recruiting
Phase 1
Evaluating the combined use of NOn-invasive Ventilation alongside preventative anticonvulsant treatment In children presenting to hospital with CErebral_Malaria and convulsions: a phase I trial
ConditionsMalaria
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Malaria
- Sponsor
- Imperial College London
- Enrollment
- 30
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Aged 3 months to 12\-years
- •2\.Hospitalised with:
- •2\.1\.Current or recent evidence of P. falciparum malaria (slide or rapid diagnostic test (RDT) positive)
- •2\.2\.Blantyre Coma Score 2 or less that persists even after correction for concurrent hypoglycaemia (defined as blood glucose \<3 mmol/L)
- •2\.3\.History of seizures in this illness
Exclusion Criteria
- •1\.Known cerebral palsy or significant neuro\-development delay (which will affect endpoint assessment)
- •2\.Skin disease or burns preventing use of the BCV
- •3\.Respiratory or cardio\-respiratory arrest prior to enrolment
- •4\.A comorbidity which clinician believes has a significant risk of poor outcome e.g. malignancy, end\-stage renal failure, major cardiac condition
Outcomes
Primary Outcomes
Not specified
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