Effect of sequential use of noninvasive ventilation (NIV) and high flow nasal therapy (HFNT) after early extubation on re-intubation rate in chest trauma patients recovering from hypoxemic acute respiratory failure: a single-center feasibility study

niversity of Palermo. Pocliclinico P. Giaccone0 个研究点目标入组 30 人开始时间: 2016年12月16日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•All of the following:
•1) age equal or higher than 18 years;
•2) Invasive Mechanical Ventilation (iMV) for at least 24h;
•3) pressure support ventilation (PSV) with a total applied pressure, i.e. positive end-expiratory pressure (PEEP) inspiratory support, < 20 cmH2O and a PEEP level between 8 and 10 cmH2O;
•4) PaO2/FiO2 between 200 and 300 mmHg
•5) PaCO2 < 45mmHg and pH > 7.35;
•6) respiratory rate (RR) < 30/min;
•7) core temperature < 38.5 degree Celtius; (8)
•8) Glasgow coma scale (GCS) equal or higher than 11;
•9) Richmond Agitation Sedation Score < 3;
•10) cough on suctioning and need for tracheobronchial suctioning less than 2 per hour.

•One of the following:
•1) hemodynamic instability i.e. systolic arterial pressure < 90 mmHg despite fluid repletion;
•2) use of vasoactive agents, i.e. vasopressin, epinephrine and norepinephrine at any dosage, and dopamine or dobutamine > 5mcg/kg/min;
•3) life-threatening arrhythmias or electrocardiographic signs of ischemia;
•4) sepsis or septic shock;
•5) ARF secondary to neurological disorders, status asthmaticus, COPD, cardiogenic pulmonary oedema;
•6) presence of tracheotomy;
•7) uncontrolled vomiting;
•8) uncontrolled agitation RASS >3 5;
•9) two or more organ failures;
•10) body mass index > 30;
•11) documented history or suspicion of obstructive sleep apnoea;
•12) unstable flail chest
•13) recent upper airway or esophageal surgery
•14) ongoing pregnancy
•15) inclusion in other research protocols.

发起方

niversity of Palermo. Pocliclinico P. Giaccone