ACTRN12616001727437
Recruiting
N/A
Effect of sequential use of noninvasive ventilation (NIV) and high flow nasal therapy (HFNT) after early extubation on re-intubation rate in chest trauma patients recovering from hypoxemic acute respiratory failure: a single-center feasibility study
niversity of Palermo. Pocliclinico P. Giaccone0 sites30 target enrollmentDecember 16, 2016
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- chest trauma
- Sponsor
- niversity of Palermo. Pocliclinico P. Giaccone
- Enrollment
- 30
- Status
- Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All of the following:
- •1\) age equal or higher than 18 years;
- •2\) Invasive Mechanical Ventilation (iMV) for at least 24h;
- •3\) pressure support ventilation (PSV) with a total applied pressure, i.e. positive end\-expiratory pressure (PEEP) inspiratory support, \< 20 cmH2O and a PEEP level between 8 and 10 cmH2O;
- •4\) PaO2/FiO2 between 200 and 300 mmHg
- •5\) PaCO2 \< 45mmHg and pH \> 7\.35;
- •6\) respiratory rate (RR) \< 30/min;
- •7\) core temperature \< 38\.5 degree Celtius; (8\)
- •8\) Glasgow coma scale (GCS) equal or higher than 11;
- •9\) Richmond Agitation Sedation Score \< 3;
Exclusion Criteria
- •One of the following:
- •1\) hemodynamic instability i.e. systolic arterial pressure \< 90 mmHg despite fluid repletion;
- •2\) use of vasoactive agents, i.e. vasopressin, epinephrine and norepinephrine at any dosage, and dopamine or dobutamine \> 5mcg/kg/min;
- •3\) life\-threatening arrhythmias or electrocardiographic signs of ischemia;
- •4\) sepsis or septic shock;
- •5\) ARF secondary to neurological disorders, status asthmaticus, COPD, cardiogenic pulmonary oedema;
- •6\) presence of tracheotomy;
- •7\) uncontrolled vomiting;
- •8\) uncontrolled agitation RASS \>3 5;
- •9\) two or more organ failures;
Outcomes
Primary Outcomes
Not specified
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