Pediatric Acute Kidney Injury (AKI) Retrospective, Real-Time and Repository Research
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Vanderbilt University Medical Center
- Enrollment
- 12108
- Locations
- 1
- Primary Endpoint
- Number of Serum Creatinine Tests Ordered
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This proposal will incorporate statistical models developed by the investigators to predict risk for acute kidney injury into our electronic medical record system, enabling an alert to notify providers of the risk status. Pediatric inpatients will be randomly assigned to be in the intervention group, for whom the notification will be implemented, or in the control group, who will receive usual care (no notification). The investigators believe the notification will increase appropriate screening for acute kidney injury and reduce the severity of acute kidney injury in the intervention group.
Detailed Description
This proposal will incorporate a logistic regression models developed by the investigators to predict risk for acute kidney injury in pediatric intensive care unit and pediatric ward patients into the electronic medical record system, enabling personalized decision support. Real-time surveillance using the risk prediction models will identify pediatric inpatients at increased risk for acute kidney injury. When patients exceed the threshold risk for acute kidney injury, the electronic medical record system will notify providers. Patients will be randomly assigned to be in the intervention group, for whom the notification will be implemented, or in the control group, for whom the notification will not display. The risk notification will be assessed for its impact on outcomes including rates of screening for acute kidney injury and the severity of acute kidney injury.
Investigators
Sara Van Driest
Assistant Professor
Vanderbilt University Medical Center
Eligibility Criteria
Inclusion Criteria
- •All admissions to the pediatric intensive care unit or pediatric wards at the Monroe Carell Junior Children's Hospital at Vanderbilt
Exclusion Criteria
- •Prior diagnosis of chronic renal disease, including dialysis and transplant
- •Admission to the Neonatal Intensive Care Unit during the current admission
Outcomes
Primary Outcomes
Number of Serum Creatinine Tests Ordered
Time Frame: Admission through Discharge (approximately 2 days to 1 week)
Measure of efficacy of the clinical decision support to lead to increased screening for acute kidney injury.
Secondary Outcomes
- Renal Replacement Therapy (number requiring RRT)(Admission through Discharge (approximately 2 days to 1 week))
- Length of Stay (days)(Admission through Discharge (approximately 2 days to 1 week))
- Acute Kidney Injury Severity (as measured by Kidney Disease Improving Global Outcomes [KDIGO] stage 1, 2 or 3)(Admission through Discharge (approximately 2 days to 1 week))
- In-hospital Mortality(Admission through Discharge (approximately 2 days to 1 week))