Comparison of DBS Targets in Obsessive-compulsive Disorder
- Conditions
- Obsessive-Compulsive Disorder
- Registration Number
- NCT01807403
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
Deep brain stimulation (DBS) has been proposed for severe and resistant obsessive-compulsive disorder. This electrical stimulation has been tested on, and shown to be effective at, different targets (subthalamic nucleus, caudate nucleus \& nucleus accumbens). However, the efficacies of each target have never been compared directly.
This protocol aims to do so, with the hypothesis that subthalamic (STN) stimulation will be more efficacious.
- Detailed Description
Deep brain stimulation has been proposed for severe and resistant obsessive-compulsive disorder (OCD). This electrical stimulation has been tested on, and shown to be effective at, different targets (subthalamic nucleus, caudate nucleus \& nucleus accumbens). However, the efficacies of each target have never been compared directly.
Therefore, bilateral subthalamic and caudate electrodes will be implanted in severe OCD patients. Efficacy of stimulation at the different targets will be assessed using a double-blind randomised crossover design.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 8
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Severity of symptoms after each phase 3 months Severity as measured by the Yale-Brown Obsession and Compulsion scale
- Secondary Outcome Measures
Name Time Method Severity of symptoms after each phase 14 months Severity as measured by the Yale-Brown Obsession and Compulsion scale
Trial Locations
- Locations (1)
Centre d'investigation Clinique Pitié Salpêtrière
🇫🇷Paris, France
Centre d'investigation Clinique Pitié Salpêtrière🇫🇷Paris, France