Effects of fentanyl(opoid analgesic) and dexmedetomidine (sedative -analgesic)on pain and discomfort associated with central venous catheter insertio
Not Applicable
- Conditions
- Health Condition 1: null- patients requiring central venous access with planned placement in the internal jugular vein as a part of normal care
- Registration Number
- CTRI/2014/02/004397
- Lead Sponsor
- Sri Venkateswara Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
patients requiring central venous access with planned placement in the internal jugular vein (IJV) as a part of normal care were consented and enrolled in the study. No systemic analgesics had been administered for at least 4 hours before the procedure.
Patients were included in the study if they were awake, alert, and oriented and their medical condition was stable enough to allow them to understand and use visual analogue scale(VAS)and were 18 to 65year old.
Exclusion Criteria
Patients were excluded from the study if they were receiving neuromuscular blocking medications or had a disease or injury that impaired sensory transmission proximal to the procedure site.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Discomfort was assessed using an 11-point verbal numeric rating discomfort scale (VNRDS) from 0 to 10 (0: none, 10: extreme discomfort); pain was assessed by a verbal numeric rating pain scale (VNRPS) from 0 to 10 (0: no pain, 10: the worst pain imaginable) .Timepoint: five time points: time 1, at base line (T1); time 2, after initial local anesthetic injection (LAI)(T2); time 3,immediately after the procedure, the patient was asked to report the peak pain experienced during the procedure (T3);time 4, 10 minutes after completion of the procedure (T10) and time 5,60 minutes after completion of the procedure (T60)
- Secondary Outcome Measures
Name Time Method Sedation was assessed on a 6-point modified Observerâ??s assessment of alertness/sedation(OAA/S) scale . <br/ ><br>Respiratory depression,Pruritus,Nausea and vomittingTimepoint: five time points: time 1, at base line (T1); time 2, after initial local anesthetic injection (LAI)(T2); time 3,immediately after the procedure, the patient was asked to report the peak pain experienced during the procedure (T3);time 4, 10 minutes after completion of the procedure (T10) and time 5,60 minutes after completion of the procedure (T60)