Impact of Amino Acids to Enhance Anabolism After Home-based Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Whole-body net leucine balance (umol/kg)
研究概览
简要总结
An adequate quantity of lean body mass is vital for optimal health and performance, and is accrued when net protein balance (NPB) is positive. Amino acids are the building blocks of protein, and when consumed following resistance exercise, significantly improve NPB.
However, no study has investigated how a supplement of all of the essential amino acids (EAA) affects NPB following resistance exercise in a free-living, home-based setting, particularly when compared to a supplement of branched-chain amino acids (BCAA).
Therefore, the purpose of this study is to determine the impact of a novel EAA supplement on anabolism (e.g., NPB) as compared to BCAA and placebo supplements following home-based resistance exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
All investigators involved with the study, as well as participants, will be blinded to treatment conditions (double-blind design) until data analysis is completed.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 18-35 years
- •Recreationally active; currently performing structured exercise (e.g., running, weight lifting, team-sport activity) at least 2 days per week
排除标准
- •Body Mass Index: >29.9kg/m^2
- •Inability to perform physical activity as determined by the Physical Activity Readiness Questionnaire
- •Inability to adhere to protocol guidelines (e.g., alcohol, habitual diet)
- •Regular tobacco use
- •Illicit drug use (e.g., growth hormone, testosterone)
- •Diagnosed medical condition under the care of a physician
- •Inability to abstain from supplements (e.g., protein, creatine, HMB, BCAA, phosphatidic acid) at least three weeks before and during trials
- •Individuals on any medications known to affect protein metabolism (e.g., corticosteroids, non-steroidal anti-inflammatories, or prescription-strength acne medications)
结局指标
主要结局
Whole-body net leucine balance (umol/kg)
时间窗: 5 hours/trial (four trials total)
Used as a proxy of whole-body protein balance, and estimated by using \[13C\]leucine ingestion and breath/urine sample collection
次要结局
- Urinary 3-methylhistidine (3-methylhistidine:creatinine ratio)(5 hours/trial (four trials total))
研究者
Daniel Moore
Associate Professor
University of Toronto