NCT01119989已完成不适用
Effects of a Supplementation With Amino-acids on Hepatic Lipid Metabolism
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- intrahepatic lipids
研究概览
简要总结
10 healthy male volunteers will be studied after
- a 6 day weight maintenance, balanced diet
- a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day
- a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained
- intrahepatic lipids (1H-MRS)
- metabolic effects of fructose ingestion (measurement of substrate oxidation, gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics)
This is a randomized, double blinded study
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •age 18-30 years
- •sex: males
- •BMI between 19 and 25 kg/m2
- •less than 3 30min- exercise session/week
排除标准
- •alcohol consumption more than 50g/week
- •consumption of drugs
- •history of diabetes in first degree relatives
- •presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication to NMR
研究组 & 干预措施
weight maintenance diet
No Intervention
weight maintenance + fructose
Placebo Comparator
干预措施: Fructose+maltodextrin placebo (Dietary Supplement)
weight maintenance diet + fructose and amino-acid
Experimental
干预措施: amino-acid + fructose (Dietary Supplement)
结局指标
主要结局
intrahepatic lipids
时间窗: after 6 days on each controlled diet
次要结局
- 13C palmitate synthesis(after 6 days on each controlled diet)
研究者
Luc Tappy, MD
Professor of Physiology
University of Lausanne
研究点 (2)
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