A Novel Neurobehavioral Intervention for Emotion Regulation in Anxiety and Depression
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Depression, Anxiety
- Sponsor
- Stanford University
- Enrollment
- 68
- Locations
- 2
- Primary Endpoint
- Distal outcomes
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The research proposes to use an innovative solution to shape brain circuits that support executive function and emotion reactivity -using targeted neurobehavioral intervention.
Detailed Description
Participants will be recruited locally in the San Francisco Bay area with certain symptoms of anxiety and depression. They will complete a clinical assessment and then take part in a cognitive-emotion training delivered online.
Investigators
Amit Etkin
Principle Investigator
Stanford University
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of depression on the SCID, a total Ham-D≥16 and Ham-D anxiety/somatization subscale ≥ 7.
Exclusion Criteria
- •Current medication for psychiatric disorders
- •Pregnant females
- •Head trauma or injury that resulted in loss of consciousness
- •MRI contraindication
Outcomes
Primary Outcomes
Distal outcomes
Time Frame: 5 months
We anticipate that anxiety and depression symptoms, explicit emotion regulation capacities and quality of life reported on self-report measures will show improvement.
Completion
Time Frame: 60 days
We anticipate that participants will complete at least 30-days of the intervention.
Proximal outcomes
Time Frame: 60 days
We anticipate that proximal measures of symptoms will show improvement following the training in terms of emotional reactivity, implicit emotion regulation, negative emotional memory bias, attentional bias for threat, executive functions behaviorally and N-back during fMRI as well as resting-state fMRI connectivity.