Efficacy of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild to Moderate Acne Vulgaris

Not Applicable

Completed

• Conditions: Acne Vulgaris
• Interventions: Drug: 25% TRICHLOROACETIC ACID; Drug: 30% salicylic acid

• Registration Number: NCT05712837
• Lead Sponsor: Combined Military Hospital Abbottabad

Brief Summary

To compare the efficacy of 25% trichloroacetic acid peel versus 30% salicylic acid peel in mild to moderate acne vulgaris.

Study Design: Randomized Control Trial. Place And Duration of Study: Department of Dermatology, CMH Abbottabad from 01 Jun 2022 to 30th Nov, 2022.

Methodology: A total of 60 patients presented with mild or moderate acne vulgaris were randomized into two groups comprising 30 patients in each group and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Patients in Group A were treated with 25% TCA peel whereas patients in Group B were treated with 30% SA peel. At the end of therapy after 12 weeks, evaluation of active acne was done by individual lesion counts (comedones, papules and pustules) and calculation of the Michaelsson acne score (MAS).

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-01
• Primary Completion: 2022-11-30
• Study Completion: 2022-11-30
• Status Verified: 2023-01
• Study First Submitted: 2023-01-18
• Study First Submitted QC: 2023-01-26
• Last Update Submitted: 2023-01-26
• Study First Posted: 2023-02-06
• Last Update Posted: 2023-02-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients with mild or moderate facial acne vulgaris presented in dermatology opd

Exclusion Criteria

• Patients with grade III or IV acne vulgaris
• patients taking any acne medications or had taken oral or topical medications in the past 4 weeks
• pregnant female patients or nursing a baby
• patients with known hypersensitivity to the formulations used in the study or a history of photosensitivity
• hypertrophic scars, keloidal tendency, active or recurrent herpes simplex infection
• active dermatosis
• unrealistic expectations

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A 25% TCA	25% TRICHLOROACETIC ACID	25% TCA peel Patients of group A were treated with 25% TCA peel and patients at 2-week intervals for a total of 12 weeks. Clinical evaluation was done at the end of therapy after 12-weeks of treatment.
Group B 30% SALICYLIC ACID	30% salicylic acid	30% SA peels Patients of group B were treated with 30 % salicylic acid peel and patients at 2 weeks interval for a total of 12 weeks.clinical evaluation was done at the end of therapy after 12 weeks of treatment

Primary Outcome Measures

Name	Time	Method
Effectiveness of 25 % trichloroacetic acid peel versus 30 % salicylic acid peel in the treatment of mild to moderate acne vulgaris	12 weeks	Michaelson acne scores (MAS) Michaelson acne scores (MAS) was used to measure the effectiveness of both peels

Trial Locations

Locations (1)

Cmh abbottabad; 🇵🇰 Abbottābād, Kpk, Pakistan