Prophylaxis of thromboembolism in critically ill patients using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone: a multicenter randomized controlled trial

Overview

2016 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/27488380 protocol 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30779530 results 2020 Results article in https://www.ncbi.nlm.nih.gov/pubmed/32095845 sub-study results (added 26/02/2020) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35595804/ Secondary analysis (added 23/05/2022) 2023 Other publications in https://pubmed.ncbi.nlm.nih.gov/36869382/ Post hoc analysis (added 06/03/2023)

Registry

who.int

Start Date

October 30, 2013

End Date

December 31, 2018

Last Updated

3 years ago

Study Type

Interventional

Sex

All

Sponsor

•Exclusion criteria as of 04/04/2017:
•1\. Patient treated with IPC for \> 24 hours in this current ICU admission.
•2\. Patient in the ICU\> 48 hours.
•3\. Patient treated with pharmacologic VTE prophylaxis with medications other than UFH or LMWH.
•4\. Inability or contraindication to applying IPC to both legs or to obtain adequate ultrasound on the lower extremities
•4\.1\. Burns in the lower extremities, lacerations, active skin infection, \& ischemic limb in the legs, large dressings at the site of IPC placement or in the thighs that prevent adequate ultrasounds
•4\.2\. Acute ischemia in the lower extremities
•4\.3\. Amputated foot or leg on one or two sides
•4\.4\. Compartment Syndrome
•4\.5\. Severe peripheral arterial disease