Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- serum vitamin D
研究概览
简要总结
This is an analysis of de-identified data collected from 240 Saudi Arabian women, 120 with breast cancer and 120 control women, to evalyate if vitamin D status is associated with breast cancer risk.
详细描述
Background: The role of vitamin D in breast cancer prevention is equivocal. Saudi Arabian women are thought to be at greater risk for vitamin D deficiency due to darker skin type and greater likelihood for reduced UVB radiation exposure. However, there is a lack of data regarding the vitamin D status of Saudi Arabian women and how this may relate to breast cancer risk.
Objective
The purpose of this research was to evaluate the association between circulating concentrations of 25(OH)D and breast cancer risk in Saudi Arabian women.
Design: A case-control study was conducted among 120 breast cancer cases and 120 controls. The study population was drawn from patients admitted to King Fahd Hospital in Jeddah, Saudi Arabia from June to August 2009. Participants completed questionnaires on diet and medical history and serum samples were collected from all women to measure circulating 25(OH)D concentrations.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Invasive breast cancer (cases) or healthy women (controls),
- •receiving standard medical check-ups at the women's clinic
- •between the ages of 18 and 75 years
- •BMI ≤ 40 kg/m2
- •residence in Saudi Arabia for more than 5 years
- •absence of chronic diseases that could affect vitamin D metabolism, including renal, hepatic, endocrine, or autoimmune disease.
排除标准
- •receiving standard medical check-ups at the women's clinic
- •less than 18 or greater than 75 years of age
- •BMI > 40 kg/m2
- •Not a resident of Saudi Arabia for more than 5 years
- •Presence of chronic diseases that could affect vitamin D metabolism, including renal, hepatic, endocrine, or autoimmune disease.
结局指标
主要结局
serum vitamin D
时间窗: cross-sectional from May 2009-August 2009
assessed serum vitamin D in cases versus controls
次要结局
未报告次要终点
研究者
Cynthia Thomson
Professor College of Public Health
University of Arizona