Platelet Rich Plasma (PRP) Injections For Knee Osteoarthritis

Completed

• Conditions: Knee Osteoarthritis
• Interventions: Procedure: PRP injections

• Registration Number: NCT04852380
• Lead Sponsor: Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari

Brief Summary

It was conducted a prospective study with a series of 153 patients treated with PRP injections in patient affected by knee osteoarthritis. One independent observer performed clinical and functional evaluations at T0 (recruitment), T1 (one month after the injection), T2 (three months after the last injection) and T3 (six months after the last injection).

The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Knee Score Society (KSS) score and the Visual Analogue Scale (VAS) were evaluated and recorded for each patient at each follow up.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2020-01-01
• Status Verified: 2021-04
• Study Completion: 2021-04-01
• Study First Submitted: 2021-04-15
• Study First Submitted QC: 2021-04-15
• Study First Posted: 2021-04-21
• Last Update Submitted: 2021-04-23
• Last Update Posted: 2021-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 153

Inclusion Criteria

• Age between 40 and 81;
• Body mass index (BMI) between 21.5 and 29.3;
• Chronic history (for at least 4 months) of knee joint pain;
• Radiographically documented knee osteoarthritis of grades 1 to 3 (Kellgren-Lawrence (K-L) radiographic classification scale)

Exclusion Criteria

• Radiographically severe documented knee osteoarthritis of grade 4 (K-L radiographic classification scale);
• Previous femur and tibia fractures;
• Knee previous surgical treatment (e.g., arthroscopy);
• Hyaluronic acid infiltration within the previous six months;
• Hemoglobin levels <10 g/dL;
• History of oncohematological disease, infections, or immunodepression

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients treated by PRP injection	PRP injections	-

Primary Outcome Measures

Name	Time	Method
Change in Visual Analogic Scale	Day 0; Month 1; Month 3; Month 6 (after the injection)	The knee pain was quantified using the Visual Analogic Scale ranging from 0 (no pain) to 10 (worst imaginable pain).

Trial Locations

Locations (1)

AOUC Policlinico di Bari - UOC Ortopedia e Traumatologia; 🇮🇹 Bari, Italy