Etoposide in Treating Patients With Advanced Ovarian or Cervical Cancer
- Conditions
- Cervical CancerOvarian Cancer
- Registration Number
- NCT00002478
- Lead Sponsor
- Gynecologic Oncology Group
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of etoposide in treating patients who have refractory, recurrent, or metastatic ovarian or cervical cancer.
- Detailed Description
OBJECTIVES: I. Determine the efficacy of prolonged oral etoposide (VP-16) in patients with advanced ovarian epithelial or cervical cancer. II. Evaluate the frequency and severity of observed adverse effects in this patient population treated with prolonged oral VP-16.
OUTLINE: Patients receive etoposide by mouth once daily on days 1-21 every 4 weeks. Patients with responding disease continue treatment for up to 12 months in the absence of disease progression or unacceptable toxicity. Patients with stable disease continue treatment for up to 6 months in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: If 4-6 responses are observed in the first 25 patients, an additional 15 patients will be entered. The estimated duration of the study is 8 months.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (47)
Johns Hopkins Oncology Center
🇺🇸Baltimore, Maryland, United States
Duke Comprehensive Cancer Center
🇺🇸Durham, North Carolina, United States
USC/Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Stanford University Medical Center
🇺🇸Stanford, California, United States
University of Chicago Cancer Research Center
🇺🇸Chicago, Illinois, United States
State University of New York Health Science Center at Brooklyn
🇺🇸Brooklyn, New York, United States
University of Colorado Cancer Center
🇺🇸Denver, Colorado, United States
Jonsson Comprehensive Cancer Center, UCLA
🇺🇸Los Angeles, California, United States
University of Alabama Comprehensive Cancer Center
🇺🇸Birmingham, Alabama, United States
Chao Family Comprehensive Cancer Center
🇺🇸Orange, California, United States
Walter Reed Army Medical Center
🇺🇸Washington, District of Columbia, United States
Indiana University Cancer Center
🇺🇸Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
University of Pennsylvania Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Arthur G. James Cancer Hospital - Ohio State University
🇺🇸Columbus, Ohio, United States
Abington Memorial Hospital
🇺🇸Abington, Pennsylvania, United States
Ireland Cancer Center
🇺🇸Cleveland, Ohio, United States
Cancer Center, University of Virginia HSC
🇺🇸Charlottesville, Virginia, United States
Tacoma General Hospital
🇺🇸Tacoma, Washington, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
CCOP - Upstate Carolina
🇺🇸Spartanburg, South Carolina, United States
Lineberger Comprehensive Cancer Center, UNC
🇺🇸Chapel Hill, North Carolina, United States
University of Massachusetts Memorial Medical Center
🇺🇸Worcester, Massachusetts, United States
Rush-Presbyterian-St. Luke's Medical Center
🇺🇸Chicago, Illinois, United States
Comprehensive Cancer Center of Wake Forest University Baptist Medical Center
🇺🇸Winston-Salem, North Carolina, United States
Simmons Cancer Center - Dallas
🇺🇸Dallas, Texas, United States
MBCCOP - Hawaii
🇺🇸Honolulu, Hawaii, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Vincent T. Lombardi Cancer Research Center, Georgetown University
🇺🇸Washington, District of Columbia, United States
Emory University Hospital - Atlanta
🇺🇸Atlanta, Georgia, United States
Cooper Hospital/University Medical Center
🇺🇸Camden, New Jersey, United States
Cancer Center of Albany Medical Center
🇺🇸Albany, New York, United States
H. Lee Moffitt Cancer Center and Research Institute
🇺🇸Tampa, Florida, United States
State University of New York Health Sciences Center - Stony Brook
🇺🇸Stony Brook, New York, United States
Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
University of Minnesota Cancer Center
🇺🇸Minneapolis, Minnesota, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
University of Rochester Cancer Center
🇺🇸Rochester, New York, United States
University of Oklahoma College of Medicine
🇺🇸Oklahoma City, Oklahoma, United States
Cleveland Clinic Cancer Center
🇺🇸Cleveland, Ohio, United States
Barrett Cancer Center, The University Hospital
🇺🇸Cincinnati, Ohio, United States
Barbara Ann Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
Albert B. Chandler Medical Center, University of Kentucky
🇺🇸Lexington, Kentucky, United States
CCOP - Ann Arbor Regional
🇺🇸Ann Arbor, Michigan, United States