NCT01621620Unknown不适用
The Role of Sympatho-vagal Balance on Different Limbs of Pain Perception in Healthy Subjects
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- The role of sympatho-vagal balance on different limbs of pain perception in healthy subjects
研究概览
简要总结
objectives
- To study the sympatho-vagal balance effect on different limbs of pain perception.
- To determine whether it is the hypertension by itself or the baroreflex activation due to blood pressure rise that is responsible for the analgesic effect of acute hypertension.
study questions
The study questions are derived from the study objectives:
- Does sympatho-vagal balance influence pain perception?
- Does sympatho-vagal balance influence diffuse noxious inhibitory control systems?
- Does sympatho-vagal balance influence temporal summation?
- Does the hypoalgesic effect to acute increase in blood pressure a result of baroreflex activation?
详细描述
Hypothesis
We hypothesize that the activation of the sympathetic system, which leads to increased hypertension, rather than the cholinergic response to increased BP, is responsible for antinociceptive effect of hypertension.
2.b objectives
- To study the sympatho-vagal balance effect on different limbs of pain perception.
- To determine whether it is the hypertension by itself or the baroreflex activation due to blood pressure rise that is responsible for the analgesic effect of acute hypertension.
2.c study questions
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy males and females with no known medical conditions, neither taking any chronic medications.
- •Ages between 20-
- •Capable of reading and signing an informed consent.
排除标准
- •Any known former medical condition by history affecting any system in the body:
- •cardiovascular - any history of angina or chest pain, known valvular disease, known arrhythmia of any kind in the past.
- •hypertension defined as SBP > 130 DBP > 90 and heart rate at rest > 90 BPM.
- •any occlusive peripheral vascular disease (lower limbs' pulses TP, DP, popliteal and femoral pulses absence on physical examination on the first session).
- •History of allergy to any drug.
- •Inability to understand the experiment procedure and sign an informed consent.
- •Any history of severe trauma trauma to the limbs.
- •Any history of neurologic or psychiatric disorder.
- •Pregnancy or on anticonceptive pills.
研究组 & 干预措施
yohimbin
Experimental
干预措施: Yohimbine (Drug)
结局指标
主要结局
The role of sympatho-vagal balance on different limbs of pain perception in healthy subjects
The outcome will be the respose to tonic heat pain on a VAS scale from 0-100 (where 0 no pain and 100 worst pain imagined) before and after administration of drugs that afect the sympathetic nervous system.
次要结局
未报告次要终点
研究者
研究点 (1)
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