Effects of Creatine and Glucoseamine/ Chondritin Sulfate Co-Supplementation in Addition to Exercise and Physical Therapy in Patients With Knee Osteoarthritis

Not Applicable

• Conditions: Knee Osteoarthritis
• Interventions: Other: Lower Extremity Resistance Exercise Training; Other: Home Exercise Plan; Device: Electrotherapy + Heating; Procedure: Joint Mobilization; Dietary Supplement: Creatine Supplementation; Dietary Supplement: Glucoseamine/ Chondritin Sulfate Supplementation

• Registration Number: NCT04423432
• Lead Sponsor: Foundation University Islamabad

Brief Summary

Osteoarthritis is the 11th highest contributor to disability world wide. In terms of conservative management of patients with knee osteoarthritis, Resistance exercise has been shown to be an effective intervention for reducing pain and cartilage degeneration and improving muscle strength, joint biomechanics and physical functioning. But, research shows that co supplementation can further augment the effects of resistance exercise. However, it is imperative to point out that the existing evidence is majorly focused on the individual effects of resistance exercise training and non-pharmacological supplementation, and is still deficient in the effects of co-supplementation in addition to resistance exercise training in patients with knee osteoarthritis.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Status Verified: 2020-06
• Study First Submitted: 2020-06-05
• Study First Submitted QC: 2020-06-08
• Last Update Submitted: 2020-06-08
• Study First Posted: 2020-06-09
• Last Update Posted: 2020-06-09
• Primary Completion: 2020-11
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Age 40-70 years
• Knee OA with history not less than three months.
• Radiological evidences of grade III or less on Kellgren classification.
• Knee pain on VNRS no more than 8/10

Exclusion Criteria

• Neuromuscular conditions that may lead to fatigue such as multiple Sclerosis
• Signs of serious pathology (e.g., malignancy, inflammatory disorder, infection).
• History of trauma or fractures in lower extremity.
• Signs of lumbar radiculopathy or myelopathy.
• History of knee surgery or replacement.
• Patients on intra-articular steroid therapy within two months before the commencement of the study.
• Impaired skin sensation.
• Impaired renal function

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Joint Mobilization	-
Creatine Supplementation	Home Exercise Plan	-
Creatine Supplementation	Joint Mobilization	-
Creatine Supplementation	Creatine Supplementation	-
Glucoseamine/ Chondritin Sulfate Supplementation	Lower Extremity Resistance Exercise Training	-
Glucoseamine/ Chondritin Sulfate Supplementation	Glucoseamine/ Chondritin Sulfate Supplementation	-
Control	Electrotherapy + Heating	-
Glucoseamine/ Chondritin Sulfate Supplementation	Electrotherapy + Heating	-
Control	Lower Extremity Resistance Exercise Training	-
Control	Home Exercise Plan	-
Creatine Supplementation	Lower Extremity Resistance Exercise Training	-
Creatine Supplementation	Electrotherapy + Heating	-
Glucoseamine/ Chondritin Sulfate Supplementation	Joint Mobilization	-
Glucoseamine/ Chondritin Sulfate Supplementation	Home Exercise Plan	-

Primary Outcome Measures

Name	Time	Method
Six Minute Walk Test	4 weeks	Six Minute Walk Test will be used to quantify walking related performance fatigability, walkind distance and walking speed.
Knee Range of Motion	4 weeks	Knee Range of Motion will be quantified by using Gonimeter
Knee Pain: Numeric Pain Rating Scale	4 weeks	Knee Pain will be quantified by using Numeric Pain Rating Scale
Knee Isometric Muscle Strength	4 weeks	Knee Isometric Muscle Strength will be quantified by using Modified Sphygmomanometer Dynamometer

Secondary Outcome Measures

Name	Time	Method
Knee Injury and Osteoarthritis Outcome Score (KOOS)	4 weeks	The KOOS is self-administered and assesses five outcomes: pain, symptoms, activities of daily living, sport and recreation function, and knee-related quality of life.
Postural Stability	4 weeks	Postural Stability will be quantified by using Biodex balance System
Body Composition	4 weeks	Body Composition will be quantified by using Bioelectrical Impedance
Fall Risk	4 weeks	Fall risk will be quantified by using Biodex balance System

Trial Locations

Locations (1)

Foundation University Institute of Rehabilitation Sciences; 🇵🇰 Islamabad, Federal, Pakistan