Cognitive Function in Healthy Volunteers Exposed to Acute Pain Before and After Administration of Remifentanil
概览
- 阶段
- 3 期
- 干预措施
- Ultiva (remifentanil) or placebo
- 疾病 / 适应症
- Cognitive Ability, General
- 发起方
- University of Aarhus
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Cognitive function
- 状态
- 已完成
- 最后更新
- 14年前
概览
简要总结
Patients with chronic pain can experience considerable changes in their cognitive function such as forgetfulness, increased absentmindedness, confusion etc. Opioids (e.g. morphine and morphine-like analgesics) are often used in treatment of acute and chronic pain and can lead to worsening of the cognitive function. The interaction between pain, treatment and cognitive function is very complex and is far from understood.
The hypothesis of the present study is that by use of experimental pain in healthy volunteers it will be possible to elucidate the interaction between pain, treatment and cognitive function.
研究者
入排标准
入选标准
- •Healthy men aged 18-65 years
- •Normal vision and hearing
- •No disease associated with cognitive dysfunction
排除标准
- •Allergic to remifentanil or patches
- •Any use of pain killers or alcohol 48hours before study start
- •Current participation in other clinical studies or participation within the last 14days before study start
- •Prescribed medication
- •Risk of developing
- •Previously alcohol- or drug addict
- •MMSE score \< 26
研究组 & 干预措施
Remifentanil
Investigate the effect of remifentanil on cognitive function in healthy volunteers by use of experimental pain models: * tonic muscle pain induced by the tourniquet pain model * cognitive tests * recording of brain activity by use of 64 channel cap
干预措施: Ultiva (remifentanil) or placebo
Placebo infusion
To blind the study and use as comparator in the investigation of the effect of remifentanil on cognitive function in healthy volunteers by use of experimental pain models: * tonic muscle induced pain by the tourniquet pain model * cognitive tests * brain activity by use of a 64 channel cap
干预措施: Ultiva (remifentanil) or placebo
结局指标
主要结局
Cognitive function
时间窗: 3 experiments each lasting for about 4-6hours - total duration of study is around 8-9month
Investigate the relationship between cognitive function and pain and treatment with remifentanil