The Prevention of Erythropoietin on Cardiac Surgery-associated Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- Number of Participants With Acute Kidney Injury
研究概览
简要总结
To testify the prevention of Erythropoietin on cardiac surgery associated-acute kidney injury, and trying to provide evidence for protecting the renal function and improving the prognosis for patients after cardiac surgery.
详细描述
Patients meet the inclusion criteria and agree to sign an informed consent will be randomly assigned into the control group or erythropoietin group.Interventions will be applied 1 day(24hrs) before the cardiac surgery. Blood and Urine samples will be collected after the surgery. By using the criterion given by KDIGO2012 and testing the biomarkers for acute kidney injury, we hope to find out if there is an association between erythropoietin administration and the occurence of acute kidney injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Preoperative hemoglobin<130g/L;
- •Surgery: valve, coronary artery bypass graft or surgery for congenital heart diseases;
- •Volunteers with informed consent.
排除标准
- •Patients combined with infection;
- •Patients with end-stage renal disease and undergoing renal replacement therapy
- •Patients with the history of thromboembolism;
- •Patients with malignant tumor and undergoing chemotherapy;
- •Patients with unmanageable hypertension (systolic pressure>200 mmHg or diastolic pressure>110mmHg);
- •Patients allergic to erythropoietin;
- •Patients injected erythropoietin within 2 weeks.
研究组 & 干预措施
control group
0.9% sodium chloride 1ml, subcutaneous injection, once, applied 1day before cardiac surgery
干预措施: 0.9% sodium chloride (Drug)
control group
0.9% sodium chloride 1ml, subcutaneous injection, once, applied 1day before cardiac surgery
干预措施: cardiac surgery (Procedure)
Erythropoietin group
10000 IU erythropoietin, subcutaneous injection, once, applied 1day before cardiac surgery
干预措施: Erythropoietin (Drug)
Erythropoietin group
10000 IU erythropoietin, subcutaneous injection, once, applied 1day before cardiac surgery
干预措施: cardiac surgery (Procedure)
结局指标
主要结局
Number of Participants With Acute Kidney Injury
时间窗: 7 days
Occurrence of acute kidney injury according to KDIGO guideline
次要结局
- Number of Participants With Renal Replacement Therapy(3 months)