Combating Alzheimer's Through Sleep and Exercise (CASE)
Overview
- Phase
- Not Applicable
- Intervention
- Exercise Routine
- Conditions
- Alzheimer Disease
- Sponsor
- University of Miami
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- Creatinine Levels
- Status
- Recruiting
- Last Updated
- 12 days ago
Overview
Brief Summary
The purpose of this research is to see how sleep and exercise affects dementia risk over time.
Investigators
Azizi Seixas
Associate Professor
University of Miami
Eligibility Criteria
Inclusion Criteria
- •Able to perform mild exercise
- •Able to wear DREEM 2 Headband
- •Able to wear a Fitbit wrist watch
- •Able to perform the Everlywell biomarker procedure
- •Able to Understand and Speak English
- •Able to operate a digital device like mobile phone, iPad, or computer
- •Self-reported history of problems with cognitive impairment: memory, concentration, and processing information
- •Only participants cognitively able and willing to provide consent will be included.
Exclusion Criteria
- •Prohibited from or unable to perform mild exercise
- •Unable to wear wrist watch or headband devices, or unable to supply pinprick blood sample for any reason
- •Unable to speak or understand English
- •Unable to use mobile device/smartphone technology
- •Unable or unwilling to consent for any reason.
Arms & Interventions
Exercise and Sleep Group
Participants in this group will take part in a guided exercise program in additional to wearing the DREEM 2 headband for 12 weeks.
Intervention: Exercise Routine
Sleep Only Group
Participants in this group will wear the DREEM 2 headband for 12 weeks.
Intervention: DREEM 2 Headband
Exercise Only Group
Participants in this group will workout twice a week for 12 weeks.
Intervention: Exercise Routine
Exercise and Sleep Group
Participants in this group will take part in a guided exercise program in additional to wearing the DREEM 2 headband for 12 weeks.
Intervention: DREEM 2 Headband
Outcomes
Primary Outcomes
Creatinine Levels
Time Frame: Up to Week 12
Measured from Urine Sample
HbA1c Levels
Time Frame: Up to Week 12
Measured from blood sample
Heart Rate
Time Frame: Up to Week 12
Measured from Fitbit
Total Sleep Duration
Time Frame: Up to Week 12
Measured from DREEM 2
Slow Wave Sleep Duration
Time Frame: Up to Week 12
Measured from DREEM 2
Triglycerides Levels
Time Frame: Up to Week 12
Measured from blood sample
High-Density Lipoprotein (HDL) Levels
Time Frame: Up to Week 12
Measured from blood sample
Blood Pressure
Time Frame: Up to Week 12
Measured from Fitbit
Cortisone Levels
Time Frame: Up to Week 12
Measured from Urine Sample
Total Cholesterol Levels
Time Frame: Up to Week 12
Measured from blood sample
Low-Density Lipoprotein (LDL) Levels
Time Frame: Up to Week 12
Measured from blood sample
High-sensitivity C-reactive protein (hs-CRP) Levels
Time Frame: Up to Week 12
Measured from blood sample
Cortisol Levels
Time Frame: Up to Week 12
Measured from Urine Sample
Melatonin Levels
Time Frame: Up to Week 12
Measured from Urine Sample