Comparison of dexmedetomidine mist inhalation to magnesium sulfate in terms of how blood pressure and hear rate responds when a doctor inserts a tube into windpipe and how often the patient gets sore throat after surgery

Phase 1

Not yet recruiting

• Conditions: ASA 1 and ASA 2 patients

• Registration Number: CTRI/2023/12/060483
• Lead Sponsor: Dr Fateh Pal Singh Gill

Brief Summary

It is a randomized, prospective, comparative, double blinded study where in pre operative nebulization with dexmedetomedine and magnesium sulphate are compared for the attenuation of hemodynamic response during laryngoscopy and edotracheal intubation before a surgical procedure under general anaesthesia.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-12-10
• Study Start: 2023-12-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• 1.ASA grade I or II fit patients.
• Patients aged between 18 and 60 years of age.
• Patients undergoing surgeries under general anaesthesia.
• Haemodynamically stable patients with all routine investigations within normal limits and without any comorbidities.
• 5.Written informed consent from the concerned patient.

Exclusion Criteria

• 1.Patients who are not willing to participate in the study.
• 2.Patients with ASA grade III and above physical status.
• 3.Patients who are aged less than 18 and more than 60 years of age.
• Patients who are posted for emergency procedures.
• Patients with known allergy to the study drugs.
• Patients with difficult intubation.
• Patients who are obese.
• Patients who have psychiatric, neurological, neuromuscular or cardiovascular disease or impairment of hepatic or renal function.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To observe the attenuation of pressor responses to laryngoscopy and endotracheal intubation with preoperative nebulization with dexmedetomidine and incidence of post operative sore throat	Pre intubation, scopy 0 minutes, every 1 minute upto 10 minutes post intubation, after extubation

Secondary Outcome Measures

Name	Time	Method
To observe the attenuation of pressor responses to laryngoscopy and endotracheal intubation with preoperative nebulization with dexmedetomidine and incidence of post operative sore throat	Pre intubation, scopy 0 minutes, every 1 minute upto 10 minutes post intubation, after extubation

Trial Locations

Locations (1)

Hightech OT complex, 5th floor, hightech building; 🇮🇳 Pune, MAHARASHTRA, India

Hightech OT complex, 5th floor, hightech building

🇮🇳Pune, MAHARASHTRA, India

Dr Fateh Pal Singh Gill

Principal investigator

9996646526

gillfateh13@yahoo.com