Validation of Drug Assays in Various Biological Matrices
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infection
- Sponsor
- University of Liverpool
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- To measure drug concentrations using high performance liquid chromatography -tandem mass spectrometry (HPLC-MS/MS) (accuracy and precision of assays that measure drug concentrations)
- Status
- Recruiting
- Last Updated
- 2 months ago
Overview
Brief Summary
This study aims to ensure that assays that measure drug concentrations are accurate and precise in different matrices when quantified using high performance liquid chromatography -tandem mass spectrometry (HPLC-MS/MS). The study involves collecting samples of various bodily fluids to quantify antimicrobials, antivirals, oral contraceptives and erectile dysfunction agents. Samples will also be obtained from individuals not receiving these medications for quality control purposes.
Investigators
Helen Reynolds
Research nurse
University of Liverpool
Eligibility Criteria
Inclusion Criteria
- •\> 18 years of age
Exclusion Criteria
- •Unable to give informed consent
Outcomes
Primary Outcomes
To measure drug concentrations using high performance liquid chromatography -tandem mass spectrometry (HPLC-MS/MS) (accuracy and precision of assays that measure drug concentrations)
Time Frame: Follow up up to 5 years
Assay validation