Effect of Inspiratory Muscle Training on Glycemic Control in Individuals With Type 2 Diabetes:Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Glycated hemoglobin in 8 weeks
研究概览
简要总结
In diabetic individuals, changes in ventilatory muscle strength and lung function have been demonstrated over the years. The onset and progression of chronic complications in diabetes should be avoided by reaching glycated hemoglobin (HbA1c) levels below 7%. The control of glycemia through the measurement of HbA1c is fundamental to avoid complications. The inspiratory muscle training has been used in several clinical situations, and may be an alternative for individuals with type 2 diabetes mellitus who have difficulties performing conventional exercises. The long-term effect of inspiratory muscle training on glycemic control has not been tested yet. The aim of this study is to evaluate the effects of inspiratory muscle training on glycemic control in individuals with type 2 diabetes.
详细描述
An acute high intensity inspiratory muscle exercise session was able to reduce glycemic levels (24%) similarly to an aerobic exercise session (25%) in subjects with type 2 diabetes, demonstrating that this type of exercise inspiratory muscle may have great potential in improving glycemic control.The present study will investigate if training of the inspiratory musculature for 8 and 12 weeks is capable of improving glycated hemoglobin, glucose and inspiratory muscle strength in individuals with type 2 diabetes. In addition, this study will evaluate the effect of inspiratory muscle training, with moderate loading of 30% of the MIP, on volumes and capacities lung in patients with type 2 diabetes. The subjects with type 2 diabetes will be recruited from the ambulatory of the Hospital de Clinicas de Porto Alegre and through newspaper advertisements.
Patients will be submitted to a general evaluation, including clinical history, physical examination, laboratory evaluation and application of the international physical activity questionnaire. Subsequently, individuals will perform assessments of lung functions (lung function assessment, ventilatory muscle strength test, inspiratory muscle strength test) and autonomic assessment (Ewing's tests). Patients will be randomized to perform inspiratory muscle training with a placebo load (MIP 2%) or with moderate intensity (MIP 30%). Upon the randomization, participants will initiate inspiratory musculature training. The exams of HbA1c, glucose and ventilatory muscle strength tests will be performed in three moments: 1) at the initial assessment, 2) in the eighth week of inspiratory muscle training, and 3) at the end of the training (twelfth) week. During inspiratory muscle training, individuals will attend on Hospital de Clinicas de Porto Alegre, once a week, to the supervision of the way the exercise is being performed. Furthermore, it will be set to load on the PowerBreathe ® device for the following week.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes;
- •30 years and older;
- •HbA1c from 7,5 to 10%.
排除标准
- •Pregnant women;
- •Pulmonary disease (chronic obstructive pulmonary disease, exercise-induced asthma, idiopathic pulmonary fibrosis, sarcoidosis and lung neoplasms);
- •Neuromuscular disease;
- •Body mass index > 35 kg/m²;
- •Individuals who perform physical exercise more than twice a week;
- •Current smoking.
研究组 & 干预措施
Inspiratory muscle training
Patients will perform the inspiratory muscle training using a load moderate of 30% of maximal inspiratory pressure (MIP 30%).
干预措施: Inspiratory muscle training. (Device)
Placebo inspiratory muscle
Patients will perform the inspiratory muscle training using a load of 2% of maximal inspiratory pressure (MIP 2%).
干预措施: Placebo inspiratory muscle (Device)
结局指标
主要结局
Glycated hemoglobin in 8 weeks
时间窗: Evaluated in 8 weeks of inspiratory muscle training
Glycated hemoglobin concentration after 8 weeks of inspiratory muscle training
Glycated hemoglobin in 12 weeks
时间窗: Evaluated in 12 weeks of inspiratory muscle training
Glycated hemoglobin concentration after 12 weeks of inspiratory muscle training
次要结局
- Ventilatory muscle resistance(Evaluated in 12 weeks of inspiratory muscle training)
- Glucose in 8 weeks(Evaluated in 8 weeks of inspiratory muscle training)
- Glucose in 12 weeks(Evaluated in 12 weeks of inspiratory muscle training)
- Respiratory muscle strength in 12 weeks(Evaluated in 12 weeks of inspiratory muscle training)
- Lung functions(Evaluated in 12 weeks of inspiratory muscle training)
- Respiratory muscle strength in 8 weeks(Evaluated in 8 weeks of inspiratory muscle training)