Effect of Oral Carbohydrate on Serum S-100β Protein and Development of Postoperative Delirium in Elderly Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 3
- 主要终点
- serum S-100β level
研究概览
简要总结
This study is to evaluate the effects of preoperative carbohydrate intake on perioperative neuroinflammation and development of delirium.
详细描述
Perioperative insulin resistance may primarily contribute to development of postoperative delirium in high risk patients. Preoperative administration of oral carbohydrate reduces insulin resistance. The investigators aimed to investigate the influence of carbohydrate loading on the serum level of S-100β, a surrogate marker of delirium, and the incidence of postoperative delirium in elderly patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing total hip replacement or total knee replacement surgery
排除标准
- •Gastro-esophageal reflux
- •Upper gastrointestinal motility disorder
- •Inflammatory bowel disease
- •Intraperitoneal malignancy history
- •Inability to perform cognitive function test
研究组 & 干预措施
Allocated to Carbohydrated group
- Patients was administered in hospital
- Randomization
- Patient was allocated to Carbohydrated group
- Patients received 400 mL of oral isotonic glucose (No NPO®, Daesang, Korea) 12 hours before anesthesia and 400 mL 2 hours before. CHL composition was standard: 12.5 g of carbohydrate per 100 mL, 12% monosaccharide, 12% disaccharide, 76% polysaccharide, 250 mOsm/kg and 50 kcal.
干预措施: Allocated to Carbohydrated group (Dietary Supplement)
Allocated to Placebo group
- Patients was administered in hospital
- Randomization
- Patient was allocated to Placebo group
- Patients received 400 mL of water 12 hours before anesthesia and 400 mL 2 hours before anesthesia.
干预措施: Allocated to Placebo group (Dietary Supplement)
结局指标
主要结局
serum S-100β level
时间窗: Postoperative 1 hr
次要结局
未报告次要终点
研究者
SeHee Na
Associate Professor MD
Gangnam Severance Hospital