COMPARATIVE EVALUATION OF HAEMODYNAMIC RESPONSE TO INTUBATION WITH PROPOFOL,KETAMINE AND KETOFOL
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Haemodynamic stability in terms of systolic blood pressure, diastolic blood pressure and mean arterial pressure are maintained when patient is induced with ketofol (combination of propofol and ketamine ) rather than when used alone as an induction agents
研究概览
简要总结
Laryngoscopy and tracheal intubation are commonly used for airway management during general anesthesia.Propofol and ketamine are commonly used as an induction agents. Propofol has cardiovascular and respiratory depressant side effects whereas ketamine stimulates the cardiovascular system elevating heart rate, blood pressure and cardiac output.We hypothesise that combination of propofol-ketamine provides better Haemodynamic stability when compared to propofol and ketamine alone because of its distinct pharmacodynamic properties
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 59.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients undergoing elective surgery under general anesthesia and with valid consent 2.ASA grade 1 and 2 patients.
排除标准
- •1.Emergency surgeries 2.Prior sensitization or allergic reaction to propofol, ketamine, soy or egg products hemodynamic instability 3.Head injury 4.Increased intracranial or intraocular pressure 5.Pregnancy.
结局指标
主要结局
Haemodynamic stability in terms of systolic blood pressure, diastolic blood pressure and mean arterial pressure are maintained when patient is induced with ketofol (combination of propofol and ketamine ) rather than when used alone as an induction agents
时间窗: Baseline , 1 minute ,3minutes , 5 minutes ,15 minutes after intubation
次要结局
- Decrease in post operative nausea and vomiting and decreased incidence of hallucinations(Immediately after extubation, 15 minutes , 30 minutes and 1 hour after extubation)