Haemodynamic response to intubation
- Conditions
- Medical and Surgical,
- Registration Number
- CTRI/2023/05/052837
- Lead Sponsor
- M REETHM
- Brief Summary
Laryngoscopy and tracheal intubation are commonly used for airway management during general anesthesia.Propofol and ketamine are commonly used as an induction agents. Propofol has cardiovascular and respiratory depressant side effects whereas ketamine stimulates the cardiovascular system elevating heart rate, blood pressure and cardiac output.We hypothesise that combination of propofol-ketamine provides better Haemodynamic stability when compared to propofol and ketamine alone because of its distinct pharmacodynamic properties
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 120
1.Patients undergoing elective surgery under general anesthesia and with valid consent 2.ASA grade 1 and 2 patients.
1.Emergency surgeries 2.Prior sensitization or allergic reaction to propofol, ketamine, soy or egg products hemodynamic instability 3.Head injury 4.Increased intracranial or intraocular pressure 5.Pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Haemodynamic stability in terms of systolic blood pressure, diastolic blood pressure and mean arterial pressure are maintained when patient is induced with ketofol (combination of propofol and ketamine ) rather than when used alone as an induction agents Baseline , 1 minute ,3minutes , 5 minutes ,15 minutes after intubation
- Secondary Outcome Measures
Name Time Method Decrease in post operative nausea and vomiting and decreased incidence of hallucinations Immediately after extubation, 15 minutes , 30 minutes and 1 hour after extubation
Trial Locations
- Locations (1)
NIMS HOSPITAL
🇮🇳Hyderabad, TELANGANA, India
NIMS HOSPITAL🇮🇳Hyderabad, TELANGANA, IndiaDr REETHMPrincipal investigator9398188515Reethammuddamalla@gmail.com