A randomized trial to determine whether circulating levels of angptl2 correlates with the improvement in cardiopulmonary fitness associated with a exercise training-based secondary prevention in coronary artery disease patients and obese subjects compared to age-matched healthy, physically active volunteers

Montreal Heart Institute (Canada)0 个研究点目标入组 80 人开始时间: 2013年2月27日最近更新: 2017年2月6日

试验速览

暂无简介。

•In phase 1, two groups (n=20 each) of healthy and physically trained volunteer members (men and women) of aged 18 to 39 years and 50 to 70 years.
•Obese subjects (n=20) aged 50 to 70 years, men and women.
•Healthy subjects are defined as men and women without cardiac, pulmonary or muscular diseases.
•Obese patients are recruited at a BMI >30 kg/m2, without cardiac, pulmonary and muscular disease.
•In phase 2 of the study, newly referred patients with CHD (n=20) aged 50 to 70 years, and obese subjects (n=20) aged 50 to 70 years, men and women.
•Inclusion criteria for CHD patients are:
•1. Documented prior acute coronary syndrome
•2. Documented coronary revascularization or documented myocardial ischemia or necrosis on myocardial scintigraphy.
•Obese patients are recruited at a BMI >30 kg/m2, without cardiac, pulmonary and muscular disease.

•Active smokers (=1 cigarette per day) are excluded.
•Exclusion criteria for healthy subjects:
•1. Dyslipidemia (total cholesterol > 5.20 mM
•2. HDL < 1.04 mM
•3. LDL > 2.60 mM
•4. Triglycerides > 1.7 mM or use of lipid-lowering therapy)
•5. Hypertension (SBP >140 or DBP >90 mmHg or use of antihypertensive medications)
•6. Treated or untreated diabetes mellitus
•7. Impaired fasting glucose (>5.6 mM)
•8. Overweight or obesity (BMI>25 kg/m2)
•9. Abdominal obesity (waist circumference >90 cm in men, 80 cm in women)
•10. Documented CHD (prior acute coronary syndrome, prior coronary revascularization, presence of myocardial ischemia or necrosis on myocardial scintigraphy), and for any other contraindication to exercise testing/training.
•Exclusion criteria for CHD patients are:
•1. Recent acute coronary event (within one month of inclusion)
•2. History of exercise-induced or severe arrhythmias, unstable angina, pacemaker or defibrillator, presence of a pulmonary or skeletal muscle disease limiting maximal exercise testing/training
•3. Body mass index (BMI) >28 kg/m2.
•Exclusion criteria for obese subjects is the presence of a pulmonary or skeletal muscle disease limiting maximal exercise testing/training.

发起方

Montreal Heart Institute (Canada)